乙型肝炎病毒基因型B、C与肝细胞性肝癌临床病理的研究

目的 探讨HBV基因型B、C与肝癌临床病理方面的关联性.方法 对58名手术切除肝癌病人的血清样本进行基因型检测.结果 HBV基因型B、C的感染率分别为31%(18/58)、69%(40/58),基因型B病人肝硬化的发病率低于基因型C(33% vs 70%,P=0.01).基因型B、C多发肿瘤的发病率为28%、7.5%(P=0.04),伴有血管侵犯的发病率为33%、10%(p=0.03).结论 HBV基因型B相关性肝癌与HBV基因型C相关性肝癌相比,肝硬化发生率低,多发肿瘤及血管侵犯发病率高.造成了肝癌病人的复发及预后的差异性.

Clinicopathological differences between hepatitis B viral genotype B and C-related resectable hepatocellular carciaom

Objective To investigate whether HBV genotypes B and C influence the clinicopath-ological features of patients with resectable HCC.Methods Stored serung samples from 58 patients with resectable HBV-related HCC were tested for HBV genotypes by a molecular method.Results Of the 193 patients undergoing resection of HCC,18(31%)and 40(69%)were infeeted with geno-types B and C,respectively.Compared with genotype C patients,genotype B patients were less likely to be associated with liver cirrhosis(33% vs 70%,P=0.01).Pathologically,genotype B patient showed a higher rate of mutiple tumor(28%vs 7.5%,P=0.04)and more vascular invasion(33% vs 10%,P=0.03)than genotype C patients.Conclusion Genotype B-related HCC is less associated with liver cirrhosis and has a higher frequency of multiple tumour as well as more vascular invision than genotype Crelated HCC.These characteristics may contribute to the recurrence patterns and prognosis of HBV-related HCC in patients with genotype B or C infection.