| 四氧嘧啶型糖尿病对小鼠消化腺形态学影响的研究 |
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| 引用本文： | 贾雪梅,齐易祥,孙骍,唐剑云,王惠珠,齐威琴.四氧嘧啶型糖尿病对小鼠消化腺形态学影响的研究[J].解剖学报,1996(3). |
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| 作者姓名： | 贾雪梅 齐易祥 孙骍 唐剑云 王惠珠 齐威琴 |
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| 作者单位： | 安徽医科大学组织学胚胎学教研室，皖南医学院组织学胚胎学教研室，安徽省医学科学研究所，安徽师范大学电镜室 |
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| 摘 要： | 用四氧嘧啶复制小鼠实验性糖尿病模型，以探讨糖尿病对各个消化腺组织结构的影响。结果发现实验性糖尿病小鼠颌下腺腺泡萎缩，颗粒曲管细胞内线粒体肿胀变性，胰腺表现为局灶性腺泡萎缩，大量炎症细胞浸润，腺泡细胞内粗面内质网扩张，线粒体肿胀变性，髓样小体增多，酶原颗粒减少。肝细胞混浊肿胀，电镜见线粒体肿胀变性，嵴断裂，粗面内质网和糖原颗粒减少。表明在实验性糖尿病状态下，各消化腺的形态结构及功能均受到一定的损害。
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| 关 键 词： | 四氧嘧啶型糖尿病，消化腺，组织学变化，小鼠 |
MORPHOLOGICAL STUDY ON THE DIGESTIVE GLANDS FROM ALLOXAN-INDUCED DIABETES MICE |
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| Jia Xuemei,Qi Yixiang,Sun Xing,Tang Jianyun,Wang Huizhu,Qi Weiqin.MORPHOLOGICAL STUDY ON THE DIGESTIVE GLANDS FROM ALLOXAN-INDUCED DIABETES MICE[J].Acta Anatomica Sinica,1996(3). |
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| Authors: | Jia Xuemei Qi Yixiang Sun Xing Tang Jianyun Wang Huizhu Qi Weiqin |
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| Abstract: | The model of alloxan-induced diabetes in mice was built in order to investigate the effects of diabetes on digestive glands.It was found that the acini partly atrophied in the diabetes submandibular gland and pancreas in which there were focal infiltration of inflammatory cells.Some of the hepatocytes appeared cloudy swelling or atrophy.Ultrastructural alteration included that the mitochondria showed vacuolar degeneration or rupture of the crista , the rough endoplasmic reticulum appeared dilatation.The quantity of the zymogen granule in pancreas acinar cells and the glycogen granule in hepatocytes were less than those of the control. The myeloid body obivously increased.The results indicate that the experimental diabetes has damaged effects on the structure and function of digestive glands in mice. |
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| Keywords: | Alloxan-induced diabetes Digestive gland Histological change Mouse |
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