Aerosolized surfactant therapy for endotoxin-induced experimental acute respiratory distress syndrome in rats |
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| Authors: | Tashiro K Yamada K Konzaki T Yamamoto K Ohmura S Kobayashi T Suzuki Y |
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| Institution: | 1Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University, Kanazawa, Japan. 2Department of Ultrastructural Research, Institute for Frontier Medical Sciences, Kyoto University, Japan*Corresponding author |
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| Abstract: | We have compared the effects of inhalation of aerosolized surfactanton experimental acute respiratory distress syndrome. Escherichiacoli endotoxin (55 (SD 20) mg kg–1) was injected intothe tracheas of 36 adult rats anaesthetized and mechanicallyventilated with pure oxygen. When the PaO2 decreased to 11.3(3.3) kPa, the animals were randomly subjected to inhalationof aerosolized modified natural surfactant (MNS) for 0 min (controlgroup), 30, 60, and 120 min. In the control group, PaO2 remainedbelow 12 kPa for 180 min. In the groups receiving inhalationof surfactant for 30 and 60 min, PaO2 increased but decreasedsoon after termination of the inhalation. In contrast, PaO2of the group receiving inhalation of surfactant for 120 mincontinued to increase, reaching 52.1 (12.5) kPa at 180 min (P<0.05vs control). Thus, we conclude that improvement in gas exchangeas a result of inhalation of MNS depends on the duration ofinhalation. Br J Anaesth 2001; 87: 266–71 |
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| Keywords: | complications acute respiratory distress syndrome aerosols equipment nebulizers anaesthetic techniques inhalation lung surfactant rat |
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