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中风脑得平冲剂对实验性兔脑血肿的作用
引用本文:李克玲,黄启福,朱陵群,蒋玉凤,邹丽琰,贾旭,李伯光,严京,成立华.中风脑得平冲剂对实验性兔脑血肿的作用[J].北京中医药大学学报,1996(4).
作者姓名:李克玲  黄启福  朱陵群  蒋玉凤  邹丽琰  贾旭  李伯光  严京  成立华
作者单位:北京中医药大学
基金项目:“八五”国家科技攻关项目
摘    要:观察中风脑得平冲剂对自体血凝块颅内注入所致的家兔脑血肿的血气值,脑组织水、伊文斯蓝(EB)、Na+、K+、Ca(2+)、Mg(2+)含量,脑系数及组织形态学结构的影响,结果表明:中风脑得平冲剂可明显地改善脑血肿后的过度通气,减少兔脑组织EB含量,增强吞噬细胞及胶质细胞的吞噬作用,加快血肿的吸收,脑组织水含量亦较病理组显著减少(P<0.01),Na+、Ca(2+)的异常升高得到改善。提示中风脑得平冲剂有保护血脑屏障的功能,对脑水肿有明显的防治作用。

关 键 词:中风脑得平冲剂  脑血肿  脑水肿  血脑屏障  

Effects of Zhong Feng Nao De Ping Granule on Experimental Cerebral Hematoma in Rabbits
Li Keling , Huang Qifu ,Zbu Lingqun ,et al..Effects of Zhong Feng Nao De Ping Granule on Experimental Cerebral Hematoma in Rabbits[J].Journal of Beijing University of Traditional Chinese Medicine,1996(4).
Authors:Li Keling  Huang Qifu  Zbu Lingqun  
Institution:Li Keling , Huang Qifu ,Zbu Lingqun , et al.
Abstract:The experimental cerebral hematoma model was prepuced by injecting autogenous clot into the rabbit intracranial part. The influences of Zhong Feng Nao De Ping Granule on blood gas, brain index, content of water,natriums kalium, calcium, magnesium in brain tissues, the change of cerebrovascular permeability and histomorphology were observed on the 3rd day, 7th day, 14th day after cerebral hematorna. The results showed that in the pathological group brain index and content of water, ventilation of lung, natrium, calcium of brain tissue were increased progressively, cerebrovascular permeability was raised obviously, specially in the side of hematoma (right brain). Zhong Feng Nao De Ping Granule could reduce cerebral edema. In treatment group brain index,content of water, natrium, calcium in brain tissue, cerebrovascular permeability and hyperventilation after cerebral hematoma were all less than that of pathological group and closed to that of control group. Results indicated that Zhong Feng Nao De Ping Granule could protect the function of bind-cerebral hairier and relieve encephaledema.
Keywords:Zhong Feng Nao De Ping Granule  Cerebral hematoma  Cerebral edema  Bind-brain hairier  Rabbit
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