| 机械性压力对肥厚性瘢痕的作用效果:前列腺素E_2的释放 |
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| 引用本文： | 王培仁. 机械性压力对肥厚性瘢痕的作用效果:前列腺素E_2的释放[J]. 中国组织工程研究与临床康复, 2002, 6(16): 2383-2383 |
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| 作者姓名： | 王培仁 |
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| 作者单位： | 商丘市第一人民医院,河南,商丘,476100 |
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| 摘 要： | 目的通过体外机械性压力导致前列腺素E2(PGE2)释放,探讨肥厚性瘢痕松解过程中产生PGE2的规律。方法从8位患者身上取得8块瘢痕切片,用酶免疫分析仪测定压力作用后切片释放PGE2浓度。结果肥厚性瘢痕(HS)中PGE2的基本水平明显低于普通性瘢痕(NS)。压力可导致肥厚性瘢痕中PGE2释放的明显增加。结论机械性压力作用于肥厚性瘢痕可导致PGE2释放,并有助于瘢痕松解。
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| 关 键 词： | 机械性压力 肥厚性瘢痕 前列腺素E2 |
| 文章编号： | 1671-5926(2002)16-2383-02 |
| 修稿时间： | 2002-05-20 |
Effects of mechanical compression on hypertrophic scars:prostaglandin E_2 release |
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| WANG Pei ren.First People's Hospital of Shangqiu,Shangqiu ,China. Effects of mechanical compression on hypertrophic scars:prostaglandin E_2 release[J]. Journal of Clinical Rehabilitative Tissue Engineering Research, 2002, 6(16): 2383-2383 |
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| Authors: | WANG Pei ren.First People's Hospital of Shangqiu Shangqiu China |
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| Affiliation: | WANG Pei ren.First People's Hospital of Shangqiu,Shangqiu 476100,China |
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| Abstract: | Objective To investigate the role of PGE2 in the process of hypertrophy remission included by mechanical compression in vitro. Methods Eight scars taken from eight patients were performed with mechanical compression, the concentration of PGE2 every scar was measured and the curve was made.Results PGE2 basal levels in hypertrophic(HS)were significantly lower than those present in normotrophic(NS), and compression induced a significant increase in the release of PGE2 in HS.Conclusion Mechanical compression induced the release of PGE2 in HS, and it helps the remission of HS. |
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| Keywords: | mechanical compression hypertrophic scars prostaglandin E2 |
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