| Abstract: | Dependence of lymphocyte blast transformation reactions (BTR) on phytohemagglutinin P, concanavalin A, and the mitogen pokeweed on the plasma 11-hydroxycorticosteroid (11-HCS) and testosterone (T) levels and the urinary excretion of 17-ketosteroids was studied in 11 dogs with experimental urogenic (urethrogenic) prostatitis produced by means of a pathogenic staphylococcus isolated from a patient with chronic prostatitis. Before the experiment, multiple correlation was found between hormonal factors and BTR indices, but this was upset 1 month after infection of the animals and restored 2 months after infection. Before the experiment the association was expressed mainly by direct correlation with 11-HCS, but 2 months after the experiment, by negative correlation with T. The homeostatic character of the hormonallymphoid dependence relative to T is suggested.Kiev Scientific-Research Institute of Diseases of the Kidney and Urinary Tract (Urology). Kiev Scientific-Research Institute of Endocrinology and Metabolism. (Presented by Academician of the Academy of Medical Sciences of the USSR N. N. Zhukov-Verezhnikov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 87, No. 6, pp. 601–604, June, 1979. |
