AIF与凋亡的关系及其相关的结直肠癌治疗研究

许多促凋亡信号转导分子作用于线粒体,引发线粒体外膜通透性的改变,从而引发潜在的促凋亡蛋白的释放.其中较为重要的一个为凋亡诱导因子(AIF).当收到致命信号后,由线粒体释放,并迅速从细胞质移位到细胞核里结合DNA并引起不依赖天冬半胱氨酸蛋白激酶(Caspase)的染色质凝集,从而导致细胞凋亡.AIF已逐步被发现在一些恶性癌细胞(如结直肠癌细胞)中具有重要作用,特别是它在细胞凋亡中的调控作用.最近一些研究成果表明,通过影响AIF释放或表达来诱导细胞凋亡已成为结直肠癌治疗的新的研究方向.

The relationship between AIF and apoptosis and the research of treatment of colorectal cancer related to AIF

Numerous pro-apoptotic signal transducing molecules act on mitochondria and provoke the permeabilization of the outer mitochondrial membrane, thereby triggering the release of pro-apoptotic proteins potentially.One of them is much important,which called apoptosis inducing factor(AIF).Upon lethal signaling,AIF released from mitochondria, which translocates, via the cytosol to the nucleus, where it binds to DNA and provokes Caspase-independent chromatin condensation and leading to apoptosis.It has been found gradually that AIF has impotant effect in some malignant cancer cells(such as colorectal carcinoma cell), especially its regulation effect in cell death.Recently some of researches indicate that inducing cell apoptosis by effecting on the releasing or expressing of AIF, has been a new research direction of colorectal carcinoma therapy.