辛伐他汀与辅酶Q10联合应用对血脂水平及C-反应蛋白的影响

目的观察辛伐他汀与辅酶Q10联合应用对血脂水平及C-反应蛋白的影响。方法88例高血压性心脏病、冠心病伴高脂血症及C-反应蛋白增高的患者,随机分成对照组43例和试验组45例。对照组患者口服辛伐他汀10mg,每日一次睡前服。试验组辛伐他汀10mg,每日一次睡前服,辅酶Q1010mg,每日3次口服。两组均口服8周。检测指标:总胆固醇、甘油三酯、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、脂蛋白-a(Lp-a)、载脂蛋白A(Apo-A)、载脂蛋白B(Apo-B)和C-反应蛋白(CRP)。结果试验组治疗前后总胆固醇、甘油三酯、LDL-C、APo-B、CRP明显降低,尤其是LDL-C差异有统计学意义(P<0.01),HDL-C、Apo-A有不同程度的升高,但差异无统计学意义(P>0.05);对照组除LDL-C水平降低外(P<0.05,P<0.01)其余各项指标治疗后较治疗前有不同程度降低,差异无统计学意义。但两组治疗后比较,差异有统计学意义。结论辛伐他汀与辅酶Q10联合应用能增强辛伐他汀降脂及抗炎作用。

The effect of combination therapy with simyastation and coenzyme Q10 on the level of blood lipids and C-reactive protein

Objective To investigate the effect of combination therapy with simyastation and coenzyme Q10 on the level of blood lipids and C-reactive protein.Methods 88 patients with hypertensive heart disease,coronary artery disease and C-reactive protein increase,were divided randomly into control group(n=43)and experimental group(n=45).The patients of control group received 10 mg/day simvastation before sleeping.Experimental group received 10 mg/day simyatation before sleeping and coenzyme Q10 three times daily,10 mg each time.The therapeutic period for each group is 8 weeks.Detection indicators:total cholesterol(TC),triglycerides(TG),low density lipoprotein(LDL-C),high density lipoprotein(HDL-C),lipoprotein-a(Lp-a),apolipoprotein A(Apo-A),apolipoprotein B(Apo-B)and C-reactive protein(CRP).Results Ccompared with experimental group of pre-and post-therapy,TC,TG,LDL-C,Apo-B and CRP are apparently decreased,especially LDL-C,which had significant statistics difference(P<0.01).HDL-C and Apo-A are also increased,but there is no significant statistics difference(P>0.05).Though all indicators decreased in control group ccompared with pre-and post-therapy except LDL-C,there is also no significant difference.While there are significant statistics difference,compared with two groups after treatment.Conclusion The antiinflammatory and raducing sebum of simyastation can be reinforced by combination therapy with simyastation and coenzyme Q10.