| 两种国产米非司酮片剂的相对生物利用度研究 |
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| 引用本文： | 石建平,苏雪清,朱艳霞,吴熙瑞. 两种国产米非司酮片剂的相对生物利用度研究[J]. 华中科技大学学报(医学版), 1993, 0(6) |
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| 作者姓名： | 石建平 苏雪清 朱艳霞 吴熙瑞 |
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| 作者单位： | 同济医科大学计划生育研究所，广西北海市人民医院药剂科，同济医科大学计划生育研究所，同济医科大学计划生育研究所 武汉 430030，北海 536000，武汉 430030，武汉 430030 |
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| 摘 要： | 12名女性健康志愿者按随机交叉试验设计、分3期先后单次口服不同来源的3种米非司酮产品,其中法国产 Ru486片剂作标准参比制剂。用高效液相色谱法测定给药后120 h内的米非司酮血浆浓度。口服 200 mg 后国产全合成米非司酮、国产半合成米非司酮及法国产 Ru486 片剂的药代动力学参数以及两种国产品的生物利用度十分相似,无显著性差异。
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| 关 键 词： | 米非司酮 相对生物利用度 药代动力学 |
The Relative Bioavailability of Two Chinese Mifepristone Tablets in Healthy Female Volunteers |
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| Shi Jianping. Su Xueqing. Zhu Yanxia et al Family Planning Research Institute,Tongji Medical University,Wuhan. The Relative Bioavailability of Two Chinese Mifepristone Tablets in Healthy Female Volunteers[J]. Journal of Huazhong University of Science and Technology(Health Sciences), 1993, 0(6) |
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| Authors: | Shi Jianping. Su Xueqing. Zhu Yanxia et al Family Planning Research Institute Tongji Medical University Wuhan |
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| Affiliation: | Shi Jianping. Su Xueqing. Zhu Yanxia et al Family Planning Research Institute,Tongji Medical University,Wuhan 430030 |
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| Abstract: | The relative bioavailabilily of two Chinese tablets (products made by total synthesis or by semi-synthesis) and French RU486 pills administered orally was investigated in a randomized three-period crossover study in 12 healthy female subjects. Plasma concentrations were measured for 120 h after each oral administration of 200 mg mifepristone. by HPLC assay with UV detection methods. There was no significant difference between these preparations in pharmacokinetic parameters including their relative bioavailability. |
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| Keywords: | mifepristone relative bioavailability pharmacokinetics |
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