Autophagy-related proteins LC3 and Beclin-1 impact the efficacy of chemoradiation on esophageal squamous cell carcinoma |
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| Authors: | Yongshun Chen Xiaohong Li Xiaoyuan Wu Chunyu He Leiming Guo Song Zhang Yanjing Xiao Wei Guo Bo Tan |
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| Institution: | 1. Department of Radiation Oncology, Zhengzhou University Affiliated Cancer Hospital, Henan Cancer Hospital, China;2. Department of Pathology, Zhengzhou University Affiliated Cancer Hospital, Henan Cancer Hospital, China;3. People''s Hospital of Zhengzhou, China;4. Department of Pathology, Zhengzhou University affiliated Zhengzhou Central Hospital, China |
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| Abstract: | Autophagy is a bulk protein and organelle degradation process essential for cellular maintenance, cell viability and development. This study investigated the prognostic role of LC3 and Beclin-1, two autophagy-related proteins, in patients with locally advanced esophageal squamous cell carcinoma (ESCC) treated with definitive chemoradiation. |
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| Keywords: | LC3 Beclin-1 Esophageal cancer Chemoradiation Prognosis |
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