Incidental perivascular epithelioid cell tumor in an inguinal hernia sac |
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Authors: | Tao Wang Harry Voogjarv Rajkumar Vajpeyi |
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Affiliation: | 1. Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada;2. Department of Surgery, Timmins and District Hospital, Timmins, Canada;3. Department of Pathology, University Health Network, Toronto, Canada |
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Abstract: | Perivascular epithelioid tumors (PEComa) are uncommon mesenchymal neoplasms demonstrating positivity for muscular and melanocytic immuno-markers. Included in this category are angiomyolipoma, lymphangioleiomyomatosis, and clear cell sugar tumors. Lesions which do not fit into these categories are classified as “not otherwise specified”. We present a case of an incidentally discovered PEComa within inguinal hernia sac contents in a 70-year-old woman. It consisted of spindled and epithelioid cells with bland oval nuclei, small nucleoli and clear to light eosinophilic cytoplasm. There was no atypia or mitoses. The lesion was strongly positive for HMB45 and smooth muscle actin. Pelvic soft tissue and peritoneal PEComas are rarely reported in literature and very little is known about their prognosis. We discuss the immunohistochemistry, differential diagnosis, and pathogenesis of PEComas. |
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Keywords: | Perivascular epithelioid cell PEComa Inguinal hernia |
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