Expression of FoxO3a in clinical cases of malignant lymphoma |
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Authors: | Jun-Ichiro Ikeda Tian TianYi Wang Yumiko HoriKeiichiro Honma Naoki WadaEiichi Morii |
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Institution: | Department of Pathology, Osaka University, Graduate School of Medicine, Yamada-oka 2-2, Suita 565-0871, Japan |
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Abstract: | Cancer-initiating cells (CICs) are a limited number of cells with tumorigenic activity. Few studies have been performed on CICs in malignant lymphoma. We recently demonstrated that a small number of FoxO3a-expressing cells possessed CIC-like potential in Hodgkin's lymphoma (HL) cell lines. In the present study, FoxO3a expression was examined immunohistochemically in 137 patients with malignant lymphoma. Among patients with HL, FoxO3a-positive tumor cells were detected in 11 of 11 with nodular sclerosis classical HL, 8 of 15 with mixed cellularity classical HL, 0 of 1 with lymphocyte-rich classical HL, and 2 of 3 with nodular lymphocyte-predominant HL. Only limited numbers of patients with non-HL expressed FoxO3a: 4 of 66 with diffuse large B-cell lymphoma, 1 of 20 with follicular lymphoma, and 1 of 5 with peripheral T-cell lymphoma, not otherwise specified. No FoxO3a expression was detected in patients with mantle cell lymphoma (n = 3), extranodal marginal zone B-cell lymphoma (n = 3), mediastinal large B-cell lymphoma (n = 1), NK/T cell lymphoma (n = 5), anaplastic large cell lymphoma (n = 2), or T-lymphoblastic lymphoma/leukemia (n = 2). These results suggest that FoxO3a is expressed mostly in patients with HL, but not in patients with non-HL. FoxO3a expression was limited to a small number of Hodgkin cells in a quiescent state. FoxO3a may be a CIC marker of HL, but not of non-HL. |
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Keywords: | FoxO3a Cancer initiating cells Malignant lymphoma |
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