Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors |
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| Authors: | Tuba Kara Ebru Serinsoz Rabia Bozdogan Arpaci Ozlem Gubur Gulhan Orekici Alper Ata Tahsin Colak Ali Arican |
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| Institution: | 1. Mersin University, Medical School, Department of Pathology, Turkey;2. Mersin University, Medical School, Department of Biostatistics, Turkey;3. Mersin University, Medical School, Department of Medical Oncology, Turkey;4. Mersin University, Medical School, Department of General Surgery, Turkey |
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| Abstract: | Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, and the majority contain KIT or PDGFRA-activating mutations. However, up to 10% of GISTs are c-kit-negative. Antibodies with increased sensitivity and specificity for the detection of c-kit-negative GIST cases may be of value, especially because some of these cases may also benefit from tyrosine kinase inhibitor therapy. |
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| Keywords: | GIST DOG1 c-kit Mutation |
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