Influence of MRE11, RAD50 and NIBRIN protein expression on survival in pancreatic carcinoma after curative resection |
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| Authors: | Klemens Horst Silke Ganzera Wolfgang Kaisers Johanna Munding Berenike Flott-Rahmel Andrea Tannapfel Hubert Zirngibl |
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| Affiliation: | 1. Department of Orthopedic Trauma Surgery, RWTH Aachen, Aachen, Germany;2. Department for General and Visceral Surgery, HELIOS Klinikum Wuppertal, Wuppertal, Germany;3. Bio-Medical-Research Center, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany;4. Institute for Pathology, Ruhr-University-Bochum, Bochum, Germany |
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| Abstract: | The MRE11/RAD50/NIBRIN complex, a protein complex that repairs DNA double-strand breaks, could serve as an early marker for new lesions in pancreatic cancer. We determined the expression of MRE11, RAD50 and NIBRIN, and their possible prognostic value regarding survival. |
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| Keywords: | MRE11 RAD50 NIBRIN Survival Pancreatic carcinoma |
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