Immunohistochemical markers in the diagnosis of papillary thyroid carcinomas: The promising role of combined immunostaining using HBME-1 and CD56 |
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| Authors: | Adela Nechifor-Boila,Angela Borda,Geneviè ve Sassolas,Zakia Hafdi-Nejjari,Franç oise Borson-Chazot,Jean Christophe Lifante,Nathalie Sturm,Marie Hé lè ne Lavé rriere,Nicole Berger,Myriam Decaussin-Petrucci |
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| Affiliation: | 1. Department of Pathology, University of Medicine and Pharmacy, 38 Gheorghe Marinescu Street, Târgu-Mures 540000, Romania;2. Registre Rhône Alpin des Cancers Thyroïdiens, Université Lyon 1, Centre de Recherche en Cancérologie de Lyon, UMR INSERM 1052, CNRS 5286, Faculté de Médecine RTH Laennec, 7-11 rue G. Paradin, 69372, Lyon Cedex 08, France;3. Department of Endocrinology, Groupe Hospitalier Est, Hospices Civils de Lyon, Université Lyon 1, 59 Boulevard Pinel 69677, Bron Cedex, France;4. Department of Endocrine Surgery, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Université Lyon 1, 69495 Pierre Bénite, France;5. Department of Pathology, Grenoble University Hospital, CHU A Michallon, DACP, IBP, RCB, Pôle de Biologie, 38043 Grenoble Cedex 9, France;6. Department of Pathology, Centre Hospitalier Lyon-Sud, Hospices Civils de Lyon, Université Lyon 1, 69495 Pierre Bénite, France |
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| Abstract: | We aimed to evaluate the expression and diagnostic value of five immunohistochemical markers (HBME-1, Galectin-3, CK19, CD56 and p63) in a very large series of unequivocal papillary thyroid carcinoma (PTC) cases, including both the classic (CPTC) and the follicular variant (FVPTC). |
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| Keywords: | Thyroid cancer Papillary Immunohistochemistry HBME-1 antigen CD56 antigen |
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