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Diagnosis of Xp11 translocation renal cell carcinomas in adult patients under 50 years: Interest and pitfalls of automated immunohistochemical detection of TFE3 protein |
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| Authors: | L Gaillot-Durand M Chevallier M Colombel J Couturier G Pierron JY Scoazec F Mege-Lechevallier |
| Institution: | 1. Service central d’anatomie et cytologie pathologiques, hôpital Edouard Herriot, 3 place d’Arsonval, 69437 Lyon cedex, France;2. Laboratoire Biomnis, Lyon, France;3. Service d’urologie, hôpital Edouard Herriot, 3 place d’Arsonval, 69437 Lyon cedex, France;4. Service de génétique oncologique, institut Curie – Hôpital, 26, rue d’Ulm, 75248 Paris cedex 05, France |
| Abstract: | Renal cell carcinomas associated with Xp11.2 translocations form a new and little known entity of the WHO 2004 classification. An immunohistochemical (IHC) test aiming at demonstrating the nuclear expression of the protein TFE3, product of a gene frequently involved in translocation, has been proposed as a diagnostic tool. The aims of this work were to define our evaluation criteria of the immunohistochemical test with the antibody anti-TFE3 and to describe new cases of renal cell carcinomas with TFE3 translocations. |
| Keywords: | Translocation renal cell carcinomas TFE3 Immunochemistry |
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