| 野生南药海南萝芙木抗炎作用研究 |
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| 引用本文： | 刘平怀,刘洋洋,陈德力,许琼情,汪春牛.野生南药海南萝芙木抗炎作用研究[J].中国实验方剂学杂志,2011,17(2):117-120. |
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| 作者姓名： | 刘平怀 刘洋洋 陈德力 许琼情 汪春牛 |
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| 作者单位： | 海南大学材料与化工学院,海南优势资源化工材料应用技术教育部重点实验室,海口,570228 |
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| 基金项目： | 国家高新技术研究发展计划(863计划)项目(2007AA021500); 海南省自然科学基金项目(309001) |
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| 摘 要： | 目的:研究海南萝芙木Rauwolfia verticillata(Lour.)Baill.var.hainanensis Tsiang水提物的抗炎作用。方法:采用2,4-二硝基氯代苯致小鼠耳肿胀模型、小鼠毛细血管通透性模型、大鼠蛋清性足跖肿胀模型以及大鼠棉花肉芽肿模型观察海南萝芙木水提物的抗炎作用。结果:1 725 mg·kg-1剂量的海南萝芙木水提物对2,4-二硝基氯代苯致小鼠耳片肿胀度的抑制率达69.64%(P<0.01);且能抑制由此引发的小鼠皮肤毛细血管通透性亢进(P<0.05);1 194 mg·kg-1剂量的该水提物对大鼠蛋清足跖肿胀和棉球肉芽肿的抑制作用与阿司匹林12.6 mg.kg-1剂量的作用相近(P<0.01)。结论:海南萝芙木具有较好的抗炎作用。
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| 关 键 词： | 海南萝芙木 抗炎 南药 水提物 |
| 收稿时间： | 2010/7/11 0:00:00 |
An Experimental Study on Anti-inflammatory Effect of Rauwolfia verticillata (Lour.)Baill.var.hainanensis Tsiang |
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| LIU Ping-huai,LIU Yang-yang,CHEN De-li,XU Qiong-qing and WANG Chun-niu.An Experimental Study on Anti-inflammatory Effect of Rauwolfia verticillata (Lour.)Baill.var.hainanensis Tsiang[J].China Journal of Experimental Traditional Medical Formulae,2011,17(2):117-120. |
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| Authors: | LIU Ping-huai LIU Yang-yang CHEN De-li XU Qiong-qing and WANG Chun-niu |
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| Institution: | LIU Ping-huai,LIU Yang-yang,CHEN De-li,XU Qiong-qing,WANG Chun-niu(Ministry of Education Key Laboratory of Application Technology of Hainan Superior Resources Chemical Materials,College of Materials and Chemical Engineering,Hainan University,Haikou 570228,China) |
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| Abstract: | Objective:To observe the effects of Rauwolfia verticillata(Lour.)Baill.var.hainanensis Tsiang(R.verticillata) on inflammation.Method: Inflammation models were established by 2,4-dinitrochlorobenzene-induced ear swelling and the swelling-induced changes of skin capillary permeability in mice,albumen-induced toe swelling in rats,and tampon embedding-caused granuloma in rats,respectively.Effects of the aqueous extract from roots of R.verticillata on the inflammation were observed.Result:The aqueous extract of ... |
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| Keywords: | Rauwolfia verticillata(Lour ) Baill var hainanensis Tsiang anti-inflammatory southern herb aqueous extract |
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