|
|||||
|
|
Permeability of round window membrane and its role for drug delivery: our own findings and literature review |
|
| Authors: | DUAN Mao-li CHEN Zhi-qiang |
| Affiliation: | 1. Department of clinical neuroscience, 171 76 Stockholm, Sweden;2. Department of Otolaryngology, Karolinska Hospital, 171 76 Stockholm, Sweden;3. Department of Otolaryngology, Affiliated Hospital of Anhui Medical University, China;4. Department of Otology and Laryngology, Harvard Medical School, 243 Charles Street, Boston, Massachusetts 02114, USA |
| Abstract: | We investigated the pharmacokinetics of caroverine in the perilymph, cerebrospinal fluid and plasma after systemic and local administrations in guinea pigs by using high-performance liquid chromatography. Auditory brainstem responses were measured to evaluate auditory functional effect. The results showed that local application was a both safe and efficient method. We further reviewed literature and pinpointed that the round window is ef-fectively local drug delivery means for future inner ear treatment. |
| Keywords: | caroverine glutamate receptor antagonist antioxidant pharmacokineties round window membrane noise-induced hearing los |
| 本文献已被 万方数据 ScienceDirect 等数据库收录！ | |