L-arginine在高原鼠肝脏缺血再灌注损伤时肠道细菌易位中的作用研究

目的:探讨肝脏缺血再灌注损伤时肠道细菌易位的机制及精氨酸能否有效改善肠道细菌易位。方法:在大鼠肝脏缺血再灌注损伤模型基础上,对门静脉血、回肠系膜淋巴结进行肠道细菌培养。结果:肝脏缺血再灌注损伤时,血液及淋巴结可能培养出大肠埃希氏菌。但精氨酸预处理组与相同阻断时间组之间无差异。结论:高原地区第一肝门阻断的时间对肠道细菌易位有显著影响,但精氨酸对肝缺血再灌注损伤的肠道细菌易位无明显的保护作用。

The Relationship between L-arginine Preconditioning and Bacterial Translocation Caused by Portal Triad Clamping in Rats at High Altitude

Objective:To investigate the mechanism of intestinal bacterial translocation caused by hepatic ischemia-reperfusion injury and whether L-arginine could effectly lighten the translocation in rats at high altitude. Methods: Using hepatic ischemia reperfusion model,samples of both blood and ileal mesenteric lymph node were cultured. Results: During the ischemia-reperfusion period, blood and ileal mesenteric lymph node could be cultured with intestinal bacterial. Conclusion: The portal triad clamping duration may have an obvious influence on the intestial bacterial translocation at high altitude. But L-arginine could not lighten the translocation in rats at high altitude.