血管肌纤维母细胞瘤的临床病理特点(附27例分析)

目的:探讨血管肌纤维母细胞瘤（angiomyofibroblastoma,AMF）的临床病理特点、诊治方法及预后。方法:回顾性分析2004 年 6 月至 2013年10月中国医科大学附属盛京医院诊治的27例血管肌纤维母细胞瘤患者的临床及病理特点、诊断治疗方法及预后情况。结果:患者发病年龄9个月-74岁（平均43.88岁）,中位年龄46岁，其中女性24例、男性3例。27例患者多无明显症状，多以发现无痛性包块为主诉。AMF的诊断主要依靠病理检查，其特征表现为肿瘤境界清楚，直径多小于5cm，肿瘤细胞圆形至梭形，核分裂象罕见，无细胞异型性，分布不均、疏密不一，可见交替分布界限不清的细胞密集区和细胞稀疏区。27例患者均采取手术治疗,均为单纯肿物切除术。随访12例，中位随访时间为2年（1个月-6年），无1例复发。结论:血管肌纤维母细胞瘤是一种好发于生育期女性的良性软组织肿瘤，临床表现无特异性，诊断主要依靠病理学检查，治疗多以手术为主，预后良好，术后复发率低。

The clinical and pathological features of angiomyofibroblastoma :An analysis of 27 cases

Objective:To investigate the clinicopathologic characteristic,diagnosis,treatment and prognosis of angiomyofibroblastoma(AMF).Methods:Retrospectively analyzed the clinical files of the 27 AMF cases in Shengjing Hopital of China Medical University from 2004 to 2013,the clinical and pathological features,diagnosis and treatment and prognosis were reviewed.Results:The mean age of the 27 patients was 43.88 years (range:9 months-74 years),the median age was 46 years.24 females and 3 males.Most of the cases showed gradually enlarged mass and no other obvious symptoms was complained.AMF's diagnosis depends on pathological examination,the 27 AMF patients were pathologically diagnosised.The tumors were well circumscribed and mush less than 5cm in maximal diameter.On microscopic examination,these tumor cells were oval or spindled,mitotic activity was typically minima,and characterized by alternating hypereelular and hypocellular areas with numerous blood vessels.All these 27 cases received operation,simple excision was performed.12 cases were followed up,median follow-up time was 2 years (range:1 month to 6 years),local recurrence did not occur many years after resection of the lesion.Conclusion:AMF is a benign mesenchymal tumor that occurs principally in the reproductive age woman,its diagnosis is according to the pathological diagnosis.The main treatment method is surgical operation,and the prognosis of AMF is good,with low recurrence after operation.