Caspase-9在乳腺浸润性导管癌组织中的表达及其临床意义 |
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引用本文: | 韦兴中,;陈朝华.Caspase-9在乳腺浸润性导管癌组织中的表达及其临床意义[J].赣南医学院学报,2014(3):346-348. |
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作者姓名: | 韦兴中 ;陈朝华 |
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作者单位: | [1]广西中医药大学附属瑞康医院肝胆腺体外科,广西南宁530001; [2]广西中医药大学,广西南宁530001 |
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摘 要: | 目的:探讨半胱氨酸天门冬氨酸特异的蛋白酶9(Caspase-9)在乳腺浸润性导管癌组织中的表达及其与临床病理因素的关系。方法:采用免疫组织化学SP方法研究38例乳腺浸润性导管癌(breast infiltrating ductal carcinoma,IDC)、32例乳腺纤维腺瘤及其肿物旁的正常乳腺组织中Caspase-9的表达水平,观察评估Caspase-9的阳性表达与患者年龄、肿瘤大小、淋巴结转移等临床病理因素的相关性,并探讨与乳腺浸润性导管癌的临床分期、组织学分级的关系。结果:乳腺浸润性导管癌、乳腺纤维腺瘤组织中的Caspase-9的阳性表达均低于正常乳腺组织(P〈0.05),且乳腺浸润性导管癌明显低度表达(P〈0.01)。其表达水平与患者年龄、肿瘤大小、淋巴结转移等不相关(P〉0.05),与临床分期、组织学分级明显负相关(P〈0.01)。结论:Caspase-9低表达与乳腺浸润性导管癌的恶化显著相关,该指标有助于乳腺浸润性导管癌的预后判断,其可能成为潜在乳腺肿瘤标志物,并成为治疗的靶点。
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关 键 词: | 乳腺浸润性导管癌 半胱氨酸天门冬氨酸特异的蛋白酶9 凋亡 |
Expression of Caspase-9 in breast infiltrating ductal carcinoma and its clinical significance |
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Institution: | WEI XING-zhong, CHEN ZHAO-hua ( 1. Department of Hepatobiliary Gland Surgery, the Ruikang Affiliated Hospital of Guangxi University of Chinese Medicine ; 2. Guangxi University of Chinese Medicine, Nanning, Guangxi 530001 ) |
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Abstract: | Objective: To investigate the expression of Caspase-9 protein in breast infiltrating ductal carcinoma( IDC) and its clinical significance. Methods: The expression of Caspase-9 was detected by streptavidin-perosidase( SP) with tissues of thirty-eight cases of IDC and thirty-two cases of fibroadenoma,including normal tissues adjacent to tumor. Positive expression of Caspase-9 relation with clinicopathological factors such as age,tumor size,lymph node metastasis were observed. Furthermore,clinical stage and histopathologic grade were explored in IDC. Results: The expression of Caspase-9in IDC tissues and fibroadenoma tissues were lower than that in adjacent normal tissues( P〈0. 05). Meanwhile,the IDC tissues was significantly down-regulated( P〈0. 01). The expression of Caspase-9 was independent of clinicopathological parameters,such as age,tumor size,lymph node metastasis( P〉0. 05). However,It had obvious negative correlation with clinical stage and histopathologic grade( P〈0. 01). Conclusion: The lower expression of Caspase-9 closely correlates to the progress of breast infiltrating ductal carcinoma. The index greatly contributes to judgment of prognosis of breast infiltrating ductal carcinoma. Indicating that Caspase-9 might be used as a tumor biomarker and a potential therapeutic target for inhibiting the invasive of breast infiltrating ductal carcinoma. |
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Keywords: | breast neoplasms Caspase-9 apoptosis |
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