自拟骨伤复元汤对胸腰椎骨折术后早期白介素-2、纤维蛋白原表达及疼痛的影响

目的：观察自拟骨伤复元汤对胸腰椎骨折术后早期白介素-2、纤维蛋白原表达及患者疼痛的影响。方法：将符合要求的80例胸腰椎骨折患者随机分为2组。对照组40例,术后给予补充血容量、抗感染等常规治疗;观察组40例,术后给予常规治疗联合口服自拟骨伤复原汤治疗。分别于术后第1天、第7天及第14天,比较2组患者血浆中白介素-2、纤维蛋白原含量的变化情况及疼痛视觉模拟评分变化情况。结果：1血浆白介素-2含量。不同时间点间血浆白介素-2的差异有统计学意义（F=98.792,P=0.000）。2组血浆白介素-2的组间差异总体上有统计学意义（F=18.916,P=0.000）。进一步比较显示,术后第1天2组患者血浆白介素-2含量的差异无统计学意义（6.20±1.03）ng·L-1,（6.50±0.85）ng·L-1,t=-0.714,P=0.475];术后第7天、第14天2组患者血浆白介素-2含量比较,组间差异有统计学意义（8.30±0.95）ng·L-1,（9.70±0.67）ng·L-1,t=-2.950,P=0.030;（10.20±1.32）ng·L-1,（11.90±1.29）ng·L-1,t=-2.431,P=0.015];时间因素与分组因素存在交互效应（F=12.417,P=0.011）。2血浆纤维蛋白原含量。不同时间点间血浆纤维蛋白原含量的差异有统计学意义（F=118.439,P=0.000）。2组患者血浆纤维蛋白原含量的组间差异总体上有统计学意义（F=0.896,P=0.049）。进一步比较显示,术后第1天2组血浆纤维蛋白原含量比较,差异无统计学意义（3.29±0.31）mg·dL-1,（3.34±0.23）mg·dL-1,t=0.277,P=0.741）];术后第7天、术后第14天,2组血浆纤维蛋白原含量比较,组间差异有统计学意义（2.98±0.16）mg·dL-1,（2.39±0.18）mg·dL-1,t=1.487,P=0.042;（2.77±0.13）mg·dL-1,（2.11±0.12）mg·dL-1,t=8.952,P=0.039];时间因素与分组因素存在交互效应（F=22.248,P=0.000）。3术后疼痛视觉模拟评分。不同时间点间术后疼痛视觉模拟评分的差异有统计学意义（F=264.972,P=0.000）。2组术后疼痛视觉模?

Effect of self-made GUSHANG FUYUAN DECOCTION on the early postoperative expression of interleukin- 2 and fibrinogen and the pain in patients with thoracolumbar vertebral fracture

Objective：To observe the effect of self-made GUSHANG FUYUAN DECOCTION on the early postoperative expression of interleukin-2 and fibrinogen and the pain in patients with thoracolumbar vertebral fracture. Methods：Eighty patients with thoracolumbar vertebral fracture enrolled in the study were randomly divided into 2 groups. The patients in control group（40 cases）were treated with postoperative conventional therapy including blood volume supplement and anti-infection drug after the surgery, while the others in observation group（40 cases）were treated with the conventional therapy combined with oral application of self-made GUSHANG FUYUAN DECOCTION. The plasma contents of intedeukin-2 and fibrinogen and the visual analogue score（VAS） of pain were observed and compared between the 2 groups at the 1 st ,7th and 14th day after the operation respectively. Results：There was statistical difference in plasma interleukin-2 contents between different time points（F = 98. 792,P = 0. 000）. There was statistical difference in the plasma interleukin-2 contents between the 2 groups （ F = 18.916, P = 0.000 ）. Further comparison indicated that there was no statistical difference in the plasma interleukin-2 contents between the 2 groups at the 1 st day after the operation（6.20 ＋/- 1.03 vs 6.50 ＋/-0.85 ng/L, t = -0. 714,P = 0.475 ）. There was statistical difference in the plasma interleukin-2 contents between the 2 groups at the 7th and 14th day after the operation respectively （ 8.30 ＋/- 0.95 vs 9.70 ＋/- 0.67 ng/L, t = - 2. 950, P = 0. 030 ; 10.20 ＋/- 1.32 vs 11.90 ＋/- 1.29 ng/L, t = - 2. 431, P = 0.015 ）. There was interaction effect between time factor and grouping factor（ F = 12. 417, P = 0.011 ）. There was statistical difference in plasma fibrinogen contents between different time points （ F = 118.439, P = 0. 000 ）. There was statistical difference in the plasma fibrinogen content between the 2 groups（ F = 0. 896 ,P = 0. 049 ）. Further comparison indicated that there was no