正交试验法优选冠心康胶囊的制备工艺研究 |
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引用本文: | 潘志,王颖航,刘凯.正交试验法优选冠心康胶囊的制备工艺研究[J].中国药品标准,2005,6(3):45-48. |
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作者姓名: | 潘志 王颖航 刘凯 |
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作者单位: | 1. 长春中医学院,长春,130021 2. 吉林省中医院,长春市,130021 3. 黑龙江省药品检验所,哈尔滨,150001 |
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摘 要: | 目的:研究冠心康胶囊的制备工艺.方法:采用正交试验法,以人参皂甙Rg1、Re及阿魏酸的提取率为测定指标,采用正交试验法对冠心康的制备工艺进行优选.结果:该制剂的最佳工艺条件为醇提部分以60%乙醇回流3次,每次2h.水提部分以8倍量水,提取3次,每次30min为最佳提取工艺.
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关 键 词: | 冠心康 正交设计 制备工艺 |
Optimization of Production Process of Guanxin Kang by Orthogonal Test |
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Authors: | Pan Zhi Wang Yinghang and Liu Kai |
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Institution: | Changchun University of Traditional Chinese Medicine, Changchun 130021;Jilin Provincial Hospital of Traditional Chinese Medicine, Changchun 130021;Heilongjiang Institute for Drug Control, Harbin 150001 |
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Abstract: | Objective:To establish a process for the preparation of Guanxin Kang.Methods:The optimum conditions of Guanxin Kang were selected with the active components Ginenoside Rg1,Ginenoside Re and Ferulic Acid as mark by orthogonal test.Results:The most favorable preparative conditions were decocting the drug with 70% alcohol,reflux-extracting for 3 times and 2 hours per pass.And adding 8-fold water as much as medicine,extracting 3 times,2h per time. |
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Keywords: | Guanxin Kang Orthogonal design extractive process |
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