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正交试验法优选冠心康胶囊的制备工艺研究
引用本文:潘志,王颖航,刘凯.正交试验法优选冠心康胶囊的制备工艺研究[J].中国药品标准,2005,6(3):45-48.
作者姓名:潘志  王颖航  刘凯
作者单位:1. 长春中医学院,长春,130021
2. 吉林省中医院,长春市,130021
3. 黑龙江省药品检验所,哈尔滨,150001
摘    要:目的:研究冠心康胶囊的制备工艺.方法:采用正交试验法,以人参皂甙Rg1、Re及阿魏酸的提取率为测定指标,采用正交试验法对冠心康的制备工艺进行优选.结果:该制剂的最佳工艺条件为醇提部分以60%乙醇回流3次,每次2h.水提部分以8倍量水,提取3次,每次30min为最佳提取工艺.

关 键 词:冠心康  正交设计  制备工艺

Optimization of Production Process of Guanxin Kang by Orthogonal Test
Authors:Pan Zhi  Wang Yinghang and Liu Kai
Institution:Changchun University of Traditional Chinese Medicine, Changchun 130021;Jilin Provincial Hospital of Traditional Chinese Medicine, Changchun 130021;Heilongjiang Institute for Drug Control, Harbin 150001
Abstract:Objective:To establish a process for the preparation of Guanxin Kang.Methods:The optimum conditions of Guanxin Kang were selected with the active components Ginenoside Rg1,Ginenoside Re and Ferulic Acid as mark by orthogonal test.Results:The most favorable preparative conditions were decocting the drug with 70% alcohol,reflux-extracting for 3 times and 2 hours per pass.And adding 8-fold water as much as medicine,extracting 3 times,2h per time.
Keywords:Guanxin Kang  Orthogonal design  extractive process  
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