| 姜黄素-羟丙基-β-环糊精包合物的制备及其理化性质研究 |
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| 引用本文： | 高振珅,王兰. 姜黄素-羟丙基-β-环糊精包合物的制备及其理化性质研究[J]. 中国药房, 2007, 18(13): 999-1000 |
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| 作者姓名： | 高振珅 王兰 |
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| 作者单位： | 陕西科技大学生命科学与工程学院,咸阳市,712081 |
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| 基金项目： | 咸阳市科技局资助项目;陕西科技大学校科研和校改项目 |
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| 摘 要： | 目的:制备姜黄素-羟丙基-β-环糊精包合物并考察其理化性质。方法:采用冷冻干燥法制备姜黄素-羟丙基-β-环糊精包合物,对其进行鉴别并考察其包合率、稳定性及水溶性等。结果:包合物冻干粉经鉴别已形成包合物,包合率为96·58%,姜黄素的稳定性及水溶性均得到改善。结论:所制包合物能显著增加药物在水中的溶解度,提高药物的稳定性。
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| 关 键 词： | 姜黄素 羟丙基-β-环糊精 包合物 制备 稳定性 水溶性 |
| 文章编号： | 1001-0408(2007)13-0999-02 |
| 修稿时间： | 2006-10-08 |
Studies on Preparation and Physicochemical Properties of Inclusion Complex of Curcumin with HP-β-Cyclodextrin |
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| GAO Zhenshen,WANG Lan. Studies on Preparation and Physicochemical Properties of Inclusion Complex of Curcumin with HP-β-Cyclodextrin[J]. China Pharmacy, 2007, 18(13): 999-1000 |
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| Authors: | GAO Zhenshen WANG Lan |
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| Abstract: | OBJECTIVE: To prepare the inclusion complex curcumin-hydroxypropyl-β -cyclodextrin (CUR-HP-β-CD) and study its physicochemical properties. METHODS: The inclusion complex of curcumin with HP-β-cyclodextrin (HP-β-CD) was prepared by freeze-drying method, and its inclusion rate, stability and water solubility were identified and examined by UV and X-ray powder diffractometry. RESULTS: The identification showed that the freeze-dried powder developed into an inclusion complex, with an inclusion rate of 96.58%. The stability and water solubility of curcumin were both improved. CONCLUSION: The water solubility and stability of curcumin is significantly improved by converting to the inclusion product CUR-HP-β-CD. |
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| Keywords: | Curcumin HP-β-cyclodextrin Inclusion complex Preparation Stability Water-solubility |
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