| 氯霉素透皮吸收作用研究 |
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| 引用本文： | 张志平 吴铁. 氯霉素透皮吸收作用研究[J]. 中国医院药学杂志, 1993, 13(5): 209-210 |
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| 作者姓名： | 张志平 吴铁 |
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| 作者单位： | 广东省广东医学院 湛江524023(张志平)，广东省广东医学院 湛江524023(吴铁) |
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| 摘 要： | 本文对氯霉素的透皮吸收作用作了进一步观察,用95%乙醇配制的含月桂氮酮溶液与不含月桂氮酮的溶液对氯霉素的透皮吸收作用没有显著性影响,24h 前者透过量虽较高,但经统计学检验没有显著性意义,而用50%乙醇配制的溶液在24h 则有显著的促进氯霉素透皮吸收作用(P<0.01),提示单用该浓度的乙醇有显著促进氯霉素的透皮吸收。
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| 关 键 词： | 氯霉素 月桂氮酮 乙醇 裸鼠皮肤 透皮吸收 |
Study on the percutaneous absorption of chloramphenicol |
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| Wu Tie Zhang Zhi-ping. Study on the percutaneous absorption of chloramphenicol[J]. Chinese Journal of Hospital Pharmacy, 1993, 13(5): 209-210 |
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| Authors: | Wu Tie Zhang Zhi-ping |
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| Abstract: | The action on the percutaneous absorption of chloramphenicol was investigated.The experiment showed that there was noobvious effect on the percutaneous absorption of chloramphenicol using liquid which contained azone with 95% alcohol,andliquid which did not contain azone;but the liquid with 50% alcohol had good effect on the percutaneous absorption(P<0.01 ).It was illustrated the 50% alcohol alone can markedly enhance the percutaneous absorption of chloramphenicol. |
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| Keywords: | chloramphenicol azone alcohol nude mice skin percutaneous absorption |
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