Genotoxicity testing of aqueous extracts of Mahwangyounpae-tang, a polyherbal formula |
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Authors: | Jeng-Yim Seo Mee-Yeon Park Tae-Young Jung Hae-Yun Choi Jong-Dae Kim Hyeung-Sik Lee Sae-Kwang Ku |
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Institution: | 1. Division of Respiratory System, Daegu Haany University, Gyeongsan 712-715, Republic of Korea;2. Department of Herbal Biotechnology, Daegu Haany University, Gyeongsan 712-715, Republic of Korea;3. Department of Anatomy and Histology, College of Oriental Medicine, Daegu Haany University, 290 Yugok-dong, Gyeongsan-si, Gyeongsangbuk-do 712-715, Republic of Korea;4. Development Team for the New Drug of Oriental Medicine (BK21 program), Daegu Haany University, Gyeongsan 712-715, Republic of Korea |
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Abstract: | Mahwangyounpae-tang (MT), consisting of 22 types of herbal extracts has been used for thousands of years in Korean traditional medicine for the oral treatment of respiratory diseases including asthma. As part of a safety evaluation of MT extracts for use in asthma, the potential genotoxicity of an aqueous MT extract was evaluated using the standard battery of tests (bacterial reverse mutation assay; chromosomal aberrations assay; mouse micronucleus assay) recommended by Korea Food and Drug Administration (KFDA). The MT extract was determined not to be genotoxic under the conditions of the reverse mutation assay, chromosomal aberrations assay and mouse micronucleus assay. Use of MT is presently expected to be safe, as anticipated intake is small compared to the doses administered in the genotoxicity assays and may, after further toxicity research, prove to be a useful anti-asthma agent. |
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Keywords: | Mahwangyounpae-tang Extracts Reverse mutation assay Chromosomal aberration assay Mouse micronucleus assay |
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