| 特异性溶瘤腺病毒治疗膀胱癌的研究进展 |
| |
| 引用本文： | 李永前,王志平. 特异性溶瘤腺病毒治疗膀胱癌的研究进展[J]. 医学综述, 2014, 0(24): 4463-4466 |
| |
| 作者姓名： | 李永前 王志平 |
| |
| 作者单位： | 兰州大学第二医院泌尿外科研究所甘肃省泌尿系统疾病研究重点实验室甘肃省泌尿系统疾病临床医学中心,兰州73000 |
| |
| 基金项目： | 国家自然科学基金（81372733）. |
| |
| 摘 要： | 溶瘤腺病毒因能够杀伤膀胱癌细胞同时对正常组织几乎没有影响而受到人们的广泛关注,对其进行了多方面的研究,其中特异性启动子调控的溶瘤腺病毒是研究热点。人们通过插入单个或多个特异性启动子构建了治疗膀胱癌的组织特异性溶瘤腺病毒来提高其靶向性、特异性和安全性。现就特异性启动子调控溶瘤腺病毒治疗膀胱癌的原理、研究进展以及存在的问题等方面进行综述。
|
| 关 键 词： | 特异性启动子 溶瘤腺病毒 膀胱癌 |
Advancement of Specific Oncolytic Adenoviruses Treatment for Bladder Cancer |
| |
| LI Yong-qian,WANG Zhi-ping. Advancement of Specific Oncolytic Adenoviruses Treatment for Bladder Cancer[J]. Medical Recapitulate, 2014, 0(24): 4463-4466 |
| |
| Authors: | LI Yong-qian WANG Zhi-ping |
| |
| Affiliation: | . (Institute of Urology,the Second Hospital of Lanzhou University,Key Laboratory of Urological Diseases in Gansu Province, Cansu Province Nephro-urological Clinical Center, Lanzhou 730000, China) |
| |
| Abstract: | Oncolytic adenovirus have drawn extensive attention, because they can kill bladder carcinoma cells with almost no effect on normal tissues. Studies have been conducted in many aspects, among which the oncolytic adenoviruses regulated by specific promoter is a hot area. Many kinds of oncolyitc adenoviruses by inserting single or multiple specific promoters to increase the specificity,targeting and safety. Here is to make a review of the research of specific promoter regulated oncolytic adenovirus treatment for bladder cancer from the perspective of the principle,the advancement, and the existing problems. |
| |
| Keywords: | Specific promoter Oncolytic adenovirus Bladder cancer |
| 本文献已被 维普 等数据库收录！ |
|
