| 仙人掌原毒性的初步研究 |
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| 引用本文： | 程东,韩晓英,冯宁,张天亮,李慧.仙人掌原毒性的初步研究[J].癌变．畸变．突变,2005(1). |
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| 作者姓名： | 程东 韩晓英 冯宁 张天亮 李慧 |
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| 作者单位： | 山东省疾病预防控制中心，山东大学公共卫生学院毒理学研究所，山东省疾病预防控制中心，山东省疾病预防控制中心，山东省疾病预防控制中心 山东 济南 250014，山东 济南 250012，山东 济南 250014，山东 济南 250014，山东 济南 250014 |
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| 摘 要： | 背景与目的:研究仙人掌原液的毒性。材料与方法:小鼠急性毒性试验、Ames试验、小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验、大鼠30 d喂养试验。结果:仙人掌原液雌、雄小鼠LD50均大于20.0 g／kg,属无毒物质;Ames试验、微核试验和精子畸形试验结果均为阴性;大鼠30 d喂养试验结果显示该样品30 d喂养对大鼠各项观察指标未见毒性作用。结论:在本次实验条件下,仙人掌原液为无毒物质,未显示有遗传毒性和亚急性毒性作用。
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| 关 键 词： | 仙人掌原液 急性毒性试验 遗传毒性试验 30 d喂养试验 |
Study of Toxicity of Juice of Cactus |
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| CHENG Dong,HAN Xiao-ying,FENG Ning,et al.Study of Toxicity of Juice of Cactus[J].Carcinogenesis,Teratogenesis and Mutagenesis,2005(1). |
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| Authors: | CHENG Dong HAN Xiao-ying FENG Ning |
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| Abstract: | BACKGROUND & AIM: To study the toxicity of juice of cactus. MATERIAL AND METHODS: Acute toxicitytest of mice, Ames test,micronucleus test of bone marrow PCE cell in mice,sperm shape abnormality test of mice,thirty days feeding study. RESULTS: Juice of cactus had no toxicity according to the acute toxicity (LD50> 20.0 g/kg) .The results of genetic toxicity test were all negative, including Ames test, micronucleus test and sperm shape abnormality test.The results of thirty days feeding study was also negative. CONCLUSION: Juice of cactus had no toxicity and had no genetic toxicity and subacute toxicity in this test. |
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| Keywords: | juice of cactus acute toxicity test genetic toxicity test thirty days feeding study |
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