| 左旋组氨酸在小鼠的抗惊厥作用 |
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| 引用本文： | 吴爱珍,汪慧菁,姚明辉. 左旋组氨酸在小鼠的抗惊厥作用[J]. 中国临床药理学与治疗学, 2003, 8(1): 15-17 |
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| 作者姓名： | 吴爱珍 汪慧菁 姚明辉 |
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| 作者单位： | 复旦大学上海医学院药理学系,上海,200032 |
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| 摘 要： | 目的：观察左旋组氨酸（L-His)对戊四唑（PTZ）和电刺激引起小鼠惊厥和电惊厥的实验方法，观察L-His对惊厥的影响及氯苯那敏对L-His的阻断作用。结果：L-His可拮抗PTZ，电刺激引起的惊厥，并呈现剂量依赖性，而氯苯那敏可部分拮抗L-His这种作用。结论：L-His具有抗惊厥作用。氯苯那每可部分拮抗L-His这种作用，提示L-His能通过血脑屏障进入中枢并产生抗惊厥作用。
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| 关 键 词： | 药理学 左旋组氨酸 惊厥 戊四唑 氯苯那敏 |
| 文章编号： | 1009-2501(2003)01-0015-03 |
| 修稿时间： | 2002-10-17 |
Anticonvulsant action of L-histidine in mice |
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| WU Ai-Zhen,WANG Hui-Jing,YAO Ming-Hui. Anticonvulsant action of L-histidine in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2003, 8(1): 15-17 |
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| Authors: | WU Ai-Zhen WANG Hui-Jing YAO Ming-Hui |
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| Affiliation: | WU Ai-Zhen,WANG Hui-Jing,YAO Ming-Hui Department of Pharmacology,Shanghai Medical College,Fudan University,Shanghai 200032 |
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| Abstract: | AIM: To observe the anticonvulsant action of L-histidine in mice. METHODS: The anticonvulsant effect of L-histidine, and the antagonism of dl-chlorpheniramine to L-histidine were observed in convulsion mice induced by pentylenetetrazole (PTZ) and electric stimulation. RESULTS: L-histidine exerted remarkable anticonvulsant action with dose-response relationship in convulsion mice induced by pentylenetetrazole and electric stimulation, and the action was partly antagonized by dl-chlorpheniramine. CONCLUSION: L-histidine has anticonvulsant effect, and the action was partly antagonized by dl-chlorpheniramine, suggesting that L-histidine can pass the BBS and enter the central nervous system. |
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| Keywords: | pharmacology L-histidine convulsion pentylenetetrazole dl-chlorpheniramine |
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