Antimicrobial phenolic derivatives from<Emphasis Type="Italic">Dendranthema zawadskii</Emphasis> var.<Emphasis Type="Italic">latilobum</Emphasis> kitamura (Asteraceae) |
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Authors: | Md Aziz Abdur Rahman Surk-Sik Moon |
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Institution: | (1) Department of Chemistry, Kongju National University, 314-701 Kongju, Korea |
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Abstract: | A phytochemical study on the root ofDendranthema zawadskii var.latilobum Kitamura, using a series of silica gel column chromatography and reversed phase C-18 HPLC chromatography, led to the isolation
of (1S, 2S)-1, 2, 3-trihydroxy-1-(3, 4-methylenedioxyphenyl)propane (1), 4-methoxycinnamic acid (2), acacetin (3) and caffeic acid methyl ester (4). The structures of these compounds were determined using spectroscopic analyses (UV, IR, HRTOFMS and NMR), with comparison
of their spectral data with previously reported values. Compound1 was isolated for the first time, with compounds2 and4 from this plant reported for the first time. The antibacterial and antifungal activities of the isolated compounds were measured
using the disc diffusion method. Also, their cytotoxicities against the cancer cell lines, A549, B16F1 and SK-Mel-2, and brine
shrimp lethalities were evaluated. |
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Keywords: | Antibacterial Antifungal Dendranthema zawadskii Cinnamic acid (1S 2S)-1 2 3-Trihydroxy-1 -(3 4-methylenedioxyphenyl) propane |
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