| MK—801对脑创伤大鼠部分脑区和垂体强啡肽A1—13含量的影响 |
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| 引用本文： | 孙学军 孙刚. MK—801对脑创伤大鼠部分脑区和垂体强啡肽A1—13含量的影响[J]. 放射免疫学杂志, 1997, 10(1): 7-9 |
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| 作者姓名： | 孙学军 孙刚 |
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| 作者单位： | 第二军医大学神经生物学教研室 200433 |
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| 摘 要： | 为探讨兴奋剂性氨基酸（ＥＡＡ）ＮＭＤＡ受体拮抗剂ＭＫ－８０１在脑创伤后脑水肿中的保护作用及其与内洙性强啡肽之间的关系，本研究利用放射免疫分析与脑水肿密度测定法，发现腹腔给予ＭＫ－８０１（１ｍｇ／ｋｇ）可以明显降低脑创伤后２４ｈ伤侧皮层与海马水肿，脑创伤后侧皮层与海马ｉｒ－ＤｙｎＡ１－１３含量明显降低（Ｐ〈０．０１），而给予ＭＫ－８０１后ｉｒ－ＤｙｎＡ１－１３，含量明显升高（Ｐ〈０．０１）。结果表明
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| 关 键 词： | MK－801 强啡肽 颅脑损伤 脑区 |
THE EFFECT OF MK-801 ON THE DYNORPHIN A_(1-13) CONTENT IN SOME BRAIN AREAS FOLLOWING BRAIN TRAUMA IN RATS |
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| Sun Xuejun Sun Gang Wang Chenghai Lu Changlin. THE EFFECT OF MK-801 ON THE DYNORPHIN A_(1-13) CONTENT IN SOME BRAIN AREAS FOLLOWING BRAIN TRAUMA IN RATS[J]. Journal of Radioimmanology, 1997, 10(1): 7-9 |
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| Authors: | Sun Xuejun Sun Gang Wang Chenghai Lu Changlin |
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| Affiliation: | Sun Xuejun Sun Gang Wang Chenghai Lu ChanglinDepartment of neurobiology Second Military MedicalUniversity,Shanghai 200433 |
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| Abstract: | In this study, The effect of MK-801, an NMDA receptor antagoist, on brain ederaa and its relationship with dynorphin A_(1-13) following brain trauma in rats were presented. To measure immunoreactive dynorphin A1-13(ir-DynA1-13) content in some brain areas and degree of brain edema in cortex and hippocampus, radioimmunoassay and specific gravimetric analysis were performed. We found that MK-801 could reduce cortex and hippocampus edema and increase the lowered content of ir-Dyn A1-13 in the same brain areas following brain trauma. The results suggested that MK-801 reduced the edema following brain trauma thro-ugh increasing the content of ir-Dyn A1-13 in these araes. |
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| Keywords: | brain trauma MK-801 dynorphin rats |
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