不同灸质,灸量对实验性阳虚大鼠中枢及外周5—HT代谢的影响

本文采用荧光检测方法观察了不同灸质、灸量对利血平化脾阳虚大鼠外周和中枢5-羟色胺(5-HT)神经递质及其代谢产物含量的影响。实验结果显示,实验性脾阳虚大鼠外周及中枢5—HT含量均显著下降(P<0.05),艾灸“足三里”穴可使其含量升高。其中强刺激可明显升高中枢大脑皮层5—HT含量(P<0.05),弱刺激能使外用血中5—HT含量明显提高(P<0.05)。烟条强弱刺激对实验性脾阳虚大鼠外周和中枢5—HT含量均无调整作用。提示艾灸的作用明显优于烟灸,其作用产生和强弱与艾灸的药、热等多重刺激及刺激量的强、弱有关。

Influence of Moxibustion in Different Qualities and Quantities on Metabolism of Central and Peripheral 5-HT in Rat of Experimental Yang-Deficiency

By adopting fluorescence testing method, we observed the contents of central and peripheral 5 - HT, nerve transmitter and its metabolites in reserpinized hypos-plenic function rats by different qualities and quantities of moxibustion. Results showed that in experimental hyposplenic function rats, there was a marked lowering of contents of central .and peripheral 5 -HT (P< 0. 05). Moxibustion on Zusanli point greatly increased its contents. When strong stimulus was administered, 5-HT contents in cerebral contex markedly increased (P<0. 05), while weak stimulus markedly increased that in peripheral blood (P<0. 05). Stimulation with cigarette didn"t yield such results, suggesting the superior action of moxibustion to cigarette. The strength of action was related to the amount and intensity of stimulation.