| 药物的肝外代谢 |
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| 引用本文： | 王羽,柳晓泉,王广基. 药物的肝外代谢[J]. 药学进展, 2004, 28(7): 289-294 |
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| 作者姓名： | 王羽 柳晓泉 王广基 |
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| 作者单位： | 中国药科大学药代研究中心,江苏,南京,21009 |
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| 基金项目： | 国家自然科学基金资助项目 (39970 86 2 )，国家86 3计划资助项目 (2 0 0 3A2Z347A)，江苏省药代动力学重点实验室资助项目 |
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| 摘 要： | 根据国内外在肝外药物代谢酶的种类、分布及生物学作用，药物肝外代谢的主要部位和代谢特点，影响药物肝外代谢的因素等方面的有关报道进行综述。肝外代谢在某些药物的代谢中发挥了重要的作用，其作用不容忽视。
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| 关 键 词： | 药物 肝外代谢 代谢物 分子生物学 |
| 文章编号： | 1001-5094(2004)07-0289-06 |
| 修稿时间： | 2004-03-24 |
Extrahepatic Metabolism of Drug |
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| WANG Yu,LIU Xiao-quan ,WANG Guang-ji. Extrahepatic Metabolism of Drug[J]. Progress in Pharmaceutical Sciences, 2004, 28(7): 289-294 |
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| Authors: | WANG Yu LIU Xiao-quan WANG Guang-ji |
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| Affiliation: | WANG Yu,LIU Xiao-quan *,WANG Guang-ji |
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| Abstract: | Extrahepatic metabolism plays an important role in the metabolisms of some drugs. The recent advances in extrahepatic metabolism of drugs, including the types of extrahepatic metabolism enzymes and their distribution as well as their biological action, the major sites of extrahepatic metabolism of drugs and their metabolic characteristics and the factors which can affect extrahepatic metabolisms of drugs, were reviewed. |
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| Keywords: | Drug Metabolism Enzyme Extrahepatic tissue |
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