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Partial body irradiation of small laboratory animals with an industrial X-ray tube |
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| Authors: | Thorsten Frenzel Carsten Grohmann Udo Schumacher Andreas Krüll |
| Affiliation: | 1. Universitätsklinikum Hamburg-Eppendorf, Ambulanzzentrum des UKE GmbH, Bereich Strahlentherapie, Martinistraße 52, 20246 Hamburg, Germany;2. Universitätsklinikum Hamburg-Eppendorf, Zentrum für Experimentelle Medizin, Institut für Anatomie und Experimentelle Morphologie, Martinistraße 52, 20246 Hamburg, Germany;1. Ceramic Physics Laboratory & Research Institute for Nanoscience, Kyoto Institute of Technology, Sakyo-ku, Matsugasaki, 606-8585 Kyoto, Japan;2. Piezotech Japan, Ltd., Mukaibata-cho, Ichijoji, 606-8326 Kyoto, Japan;3. Department of Medical Engineering for Treatment of Bone and Joint Disorders, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0854, Japan;4. The Center for Advanced Medical Engineering and Informatics, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan;1. School of Geosciences, China University of Petroleum, Qingdao 266580, Shandong Province, China;2. Department of Nuclear Engineering, North Carolina State University, Raleigh, NC 27695, USA;3. Maxwell Dynamics, Inc., Houston, TX 77074, USA;1. Faculty of Mechanical Engineering, Brno University of Technology, Czech Republic;2. CEITEC - Central European Institute of Technology, Brno University of Technology, Czech Republic;3. Faculty of Medicine and Dentistry, Palacký University Olomouc, Czech Republic;1. Harvard Medical School, Boston, Massachusetts, USA;2. Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA |
| Abstract: | AimsDedicated precise small laboratory animal irradiation sources are needed for basic cancer research and to meet this need expensive high precision radiation devices have been developed. To avoid such expenses a cost efficient way is presented to construct a device for partial body irradiation of small laboratory animals by adding specific components to an industrial X-ray tube.Methods and materialsA custom made radiation field tube was added to an industrial 200 kV X-ray tube. A light field display as well as a monitor ionization chamber were implemented. The field size can rapidly be changed by individual inserts of MCP96 that are used for secondary collimation of the beam. Depth dose curves and cross sectional profiles were determined with the use of a custom made water phantom. More components like positioning lasers, a custom made treatment couch, and a commercial isoflurane anesthesia unit were added to complete the system.ResultsWith the accessories described secondary small field sizes down to 10 by 10 mm2 (secondary collimator size) could be achieved. The dosimetry of the beam was constructed like those for conventional stereotactical clinical linear accelerators. The water phantom created showed an accuracy of 1 mm and was well suited for all measurements. With the anesthesia unit attached to the custom made treatment couch the system is ideal for the radiation treatment of small laboratory animals like mice.ConclusionIt was feasible to shrink the field size of an industrial X-ray tube from whole animal irradiation to precise partial body irradiation of small laboratory animals. Even smaller secondary collimator sizes than 10 by 10 mm2 are feasible with adequate secondary collimator inserts. Our custom made water phantom was well suited for the basic dosimetry of the X-ray tube. |
| Keywords: | Small animal irradiation water phantom kV dosimetry Kleintierbestrahlung Wasserphantom kV-Dosimetrie |
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