Role of miR-181 family in regulating vascular inflammation and immunity |
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| Authors: | Xinghui Sun Alan Sit Mark W. Feinberg |
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| Affiliation: | 1. Department of Microbiology, College of Medicine, Soonchunhyang University, South Korea;2. Institute of Tissue Regeneration, College of Medicine, Soonchunhyang University, South Korea;1. Department of Cardiology, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People''s Hospital, Yichang 443003, China;2. Department of Central Experimental Laboratory, The First College of Clinical Medical Science, China Three Gorges University & Yichang Central People''s Hospital, Yichang 443003, China;3. Yichang Key Laboratory of Ischemic Cardiovascular and Cerebrovascular Disease Translational Medicine, China;1. Department of Clinical and Molecular Sciences, DISCLIMO, Università Politecnica delle Marche, Ancona, Italy;2. Scientific Direction, IRCCS INRCA, Ancona, Italy;3. Diabetic Clinic, IRCCS INRCA, Ancona, Italy;4. Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294, USA;5. Center of Clinical Pathology and Innovative Therapy, IRCCS INRCA, Ancona, Italy |
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| Abstract: | The microRNA family, miR-181, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Accumulating evidence supports a central role for the miR-181 family in vascular inflammation by controlling critical signaling pathways, such as downstream NF-κB signaling, and targets relevant to endothelial cell activation and immune cell homeostasis. This review examines the current knowledge of the miR-181 family's role in key cell types that critically control cardiovascular inflammation under pathological and physiological stimuli. |
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