针刺泻法对高血压中医证候及血清NO、ET-1水平的影响

目的观察针刺泻法对高血压的临床疗效、中医证候及血清一氧化氮(NO)、内皮素-1(ET-1)水平的影响。方法将60例高血压病人随机分为针刺泻法组、针刺留针组及假针刺组,每组20例。所有病人均进行常规西药降压治疗,3组分别用不同的手法针刺太冲穴,均以28 d为1个疗程,治疗1个疗程后判定疗效。观察治疗前后血压、中医证候及血清NO、ET-1水平变化。结果治疗后,针刺泻法组与针刺留针组均较假针刺组降压效果更明显(P<0.05),针刺泻法组较针刺留针组降压效果更明显(P<0.05);治疗后,针刺泻法组及针刺留针组中医证候疗效均优于假针刺组(P<0.05);治疗后,针刺泻法组与针刺留针组血浆ET-1和血清NO水平与假针刺组比较,差异均有统计学意义(P<0.05);与针刺留针组比较,针刺泻法组血清NO水平升高更明显(P<0.05)。结论针刺太冲穴治疗能明显改善高血压病人降压效果、中医证候及血清ET-1、NO水平,其治疗高血压的作用机制可能与其对血管内皮细胞功能的双向调节密切相关。

Influences of Reduction Methods of Acupuncture on TCM Syndrome,Serum NO and ET-1 in the Treatment of Hypertension

Objective To observe the effect of reduction methods of acupuncture on clinical efficacy,TCM syndrome,and the levels of nitric oxide(NO)and endothelin-1(ET-1)in the treatment of hypertension.Methods Sixty patients with hypertension were randomly divided into acupuncture reduction group,acupuncture retained group,and sham-acupuncture group,with 20 patients in each group.All patients were treated with conventional antihypertensive drugs and acupunctured the"Taichong point"by different methods.All three groups were treated for 28 days as a course of treatment.The therapeutic effect was determined after one course of treatment,and the changes of blood pressure,TCM syndromes,and serum NO and ET-1 were observed before and after treatment.Results After treatment,the antihypertensive effect in acupuncture reduction group and acupuncture retained group were significantly better than that in sham-acupuncture group(P<0.05),and the improvement was more obvious in acupuncture reduction group than that in acupuncture retained group(P<0.05).The curative effect of TCM syndrome in acupuncture reduction group and acupuncture retained group were significantly better than that in sham-acupuncture group(P<0.05).The serum NO and ET-1 levels in acupuncture reduction group and acupuncture retained group were significantly better than that in sham-acupuncture group(P<0.05).Compared with acupuncture reduction group,the serum NO level significantly increased in acupuncture reduction group,and the difference was statistically significant(P<0.05).Conclusion Acupuncture Taichong point treatment can improve the antihypertensive effect,TCM syndrome,and serum indicators,and the acupuncture reduction was better than the acupuncture retention.The mechanism may be closely related to the bidirectional regulation of vascular endothelial cell function.