The role of microRNA profiling in prognosticating progression in Ta and T1 urinary bladder cancer |
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Authors: | Ulrika Segersten Yael Spector Yaron Goren Sarit Tabak Per-Uno Malmström |
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Affiliation: | 1. Department of Surgical Sciences, Uppsala University, Uppsala, Sweden;2. Rosetta Genomics Ltd, Rehovot, Israel |
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Abstract: | ObjectiveTo analyze microRNA profile in Ta and T1 urinary bladder cancers in combination and separately and to relate this to the risk of later developing higher-stage disease.Materials and methodsFormalin-fixed, paraffin-embedded samples of 44 Ta and 42 T1 bladder cancers representing cases with and without stage progression during follow-up were collected and microRNA expression levels were measured by microarray analysis.ResultsIn a comparison between the progressors and controls, in the Ta/T1 group, miR-10a-5p and miR-31-5p were differentially expressed. miR-10a-5p was also correlated to time to progression (P = 0.00012). In the subgroup analysis, 3 microRNAs, miR-10a-5p, miR-31-5p, and miR-130a-3p, were differentially expressed among Ta tumors and had a fold change of more than 1.5 (P<0.038). The comparison concerning microRNA expression between the progressors and controls in category T1 cancers revealed no significant differences.ConclusionsProfiling revealed that certain microRNAs predicted the risk of developing higher-stage disease among patients with Ta cancers. Lower miR-10a-5p expression in Ta progressing tumors indicates that this microRNA could be important for later malignant potential among this group of patients. |
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Keywords: | Bladder neoplasms MicroRNA Prognosis Case-control study |
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