子宫内膜异位综合征患者血清AMH和IGF-1水平表达对不孕症术后妊娠的影响

目的 探讨血清抗苗勒管激素(AMH)、血清胰岛素样生长因子-1(IGF-1)对子宫内膜异位综合征不孕患者不孕症术后妊娠的影响.方法 回顾性分析濮阳市安阳地区医院2016年3月～2018年3月收治的112例子宫内膜异位综合征不孕患者临床资料,所有患者均行根治手术,根据患者术后1年内自然妊娠情况分为妊娠组51例和未妊娠组6...

Effect of Serum AMH and IGF-1 Expression Levels on Postoperative Pregnancy in Infertility Patients with Endometriosis Syndrome

Objective To investigate the effect of preoperative expression level of anti Mullerian hormone(AMH)and insulin like growth factor-1(IGF-1)on postoperative pregnancy in infertility patients with endometriosis syndrome.Methods The clinical data of 112 infertile patients with endometriosis syndrome from March 2016 to March 2018 were analyzed retrospectively.All patients underwent radical surgery,and were divided into the pregnancy group(n=51)and the non-pregnancy group(n=61)according to the natural pregnancy status within 1 year after the operation.Pregnancy group was further divided into two subgroups according to whether the postoperative pregnancy times was within 6 months after operation,group A(n=18,<6mon)and group B(n=33,6 mon~12mon).The expression level of AMH and IGF-1 was compared between groups and subgroups.Spearman correlation was used to analyze the relationship between AMH and IGF-1 levels and postoperative natural pregnancy and natural pregnancy time.Results The preoperative levels of AMH and IGF-1 in the pregnancy group were significantly higher than those in the non-pregnant group,with statistic difference(t=11.494,5.767,all P<0.05).After operation,the postoperative levels of two indicators were still higher in the pregnancy group than those in the non-pregnancy group,with statistic difference(t=12.702,5.957,all P<0.05).The preoperative levels of AMH and IGF-1 in the group A were significantly higher than those in the group B,with statistic difference(t=3.674,2.053,all P<0.05).After operation,the levels of AMH and IGF-1 were still higher in the group A than those in the group B(t=3.032,2.526,all P<0.05).AMH and IGF-1 levels were positively correlated with postoperative natural pregnancy(r=0.547,0.481,all P<0.001)and negatively correlated with postoperative natural pregnancy time(r=-0.446,-0.521,all P<0.001).Conclusion High preoperative expression level of AMH and IGF-1 in infertile patients with endometriosis can improve the rate of postoperative natural pregnancy and reduce the time of natural pregnancy.