冠心病PCI术后应用阿司匹林加小剂量替罗非班对其血栓形成的预防效果及心功能的影响研究

目的探讨选用阿司匹林、小剂量替罗非班联合方案对冠心病经皮冠状动脉介入术(PCI)后患者血栓形成的预防效果及对心功能的影响。方法前瞻性选取2019年1月至2020年1月重庆市綦江区人民医院收治的120例接受冠心病PCI术患者,按随机数字表分为2组,对照组(n=60)患者给予氯吡格雷、阿司匹林联合治疗,观察组(n=60)患者给予氯吡格雷、阿司匹林联合小剂量替罗非班治疗。观察患者血栓以及血小板减少症发生情况、出血并发症发生状况以及心功能各项指标射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]水平变化情况等。结果观察组患者治疗后血栓总发生率为3.33%,与对照组的13.33%比较显著降低,差异有统计学意义(P<0.05);观察组患者治疗后血小板减少症发生率与出血并发症发生率分别为15.00%、13.33%,与对照组的10.00%、10.00%比较,差异无统计学意义(P>0.05);治疗后,观察组LVEF水平、LVEDD水平以及LVESD水平分别为(51.10±5.23)%、(47.02±2.10)mm、(33.37±1.30)mm,与对照组的(50.11±1.14)%、(47.01±2.17)mm、(33.38±1.34)mm比较,差异无统计学意义(P>0.05)。结论冠心病PCI术后患者选用阿司匹林、小剂量替罗非班联合方案进行治疗对其心功能具有相应的改善效果,且其血栓、血小板减少症以及出血并发症等发生率均较低,预后效果良好,值得推广。

Effects of aspirin and low-dose tirofiban on thrombosis and cardiac function in patients with coronary heart disease after PCI

Objective To investigate the effect of combination of aspirin and low-dose tirofiban on prevention of thrombosis and cardiac function in patients after percutaneous coronary intervention(PCI).Methods A prospective selection of 120 patients undergoing PCI for coronary heart disease admitted to the People's Hospital of Qijiang District from January 2019 to January 2020 were divided into 2 groups according to a random number table.The patients in the control group(60 cases)were treated with aspirin and clopidogrel,patients in the observation group(60 cases)were treated with clopidogrel,aspirin and low-dose tirofiban,the incidence of thrombus and thrombocytopenia,bleeding complications and changes of cardiac functionleft ventricular ejection fraction(LVEF),left ventricular end diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)]were observed.Results The total incidence of Thrombus in the observation group was 3.33%,which was significantly better than that in the control group(P<0.05).After treatment,the incidence of thrombocytopenia and bleeding complications in the observation group were 15.00%and 13.33%,respectively,compared with the control group 10.00%and 10.33%,there was no significant difference between the two groups(P>0.05).LVEF,LVEDD and LVESD were(51.10±5.23)%,(47.02±2.10)mm,(33.37±1.30)mm,respectively,compared with the control group(50.11±1.14)%,(47.01±2.17)mm,(33.38±1.34)mm,there was no significant difference(P>0.05).Conclusion The combination of aspirin and low-dose tirofiban can improve the cardiac function of patients with coronary heart disease after PCI,the incidence of thrombosis,thrombocytopenia and bleeding complications are low,and the prognosis is good,and it is worth spreading.