高通量测序技术检测孕早期自然流产绒毛样本染色体异常发生的Meta分析

目的 通过单组率的Meta分析,探索早期流产绒毛样本染色体异常发生情况.方法 以自然流产、高通量测序技术等为检索词在CNKI,Pubmed等相关中英文数据库等进行检索,筛选纳入高通量测序技术检测孕早期自然流产绒毛样本染色体异常发生情况的文献,采用Revman 4.3软件进行荟萃分析.结果 该研究共纳入12篇文献,723...

Incidence of the Chromosomal Abnormality of the Early Abortion Villi Samples by the Next Generation Sequence:A Meta-Analysis

Objective To explore the incidence of the chromosomal abnormality of the early abortion villi samples using the next generation sequence with a Meta-analysis.Methods The CNKI,Pubmed and other related Chinese and English database were retrieved to screen the literature that included the incidence of the chromosomal abnormality of the early abortion villi samples using the high throughput sequencing.Revman 4.3 software was used for meta-analysis.Results A total of 12 articles were included in the analysis,which includes 723 early abortion villi samples.Meta-analysis showed that there were 477 samples of chromosomal abnormality in 723 early abortion villi samples,the overall abnormal rate was 68%(0.58~0.76),the incidence rates of chromosomal abnormal number were 50%(0.43~0.57),and the incidence rates of chromosomal segmental deletion or duplication was 16%(0.09~0.24).Conclusion The next generation sequence technology can be used as the key means to detect the abnormality chromosomal in these early abortion villi samples.The abnormality of chromosomal is an important cause of spontaneous abortion in early pregnancy.