Association between IVS3 + 17T/C CD28 gene polymorphism and the acute kidney allograft rejection |
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| Authors: | Andrzej Pawlik Ewa Dabrowska-Zamojcin Violetta Dziedziejko Krzysztof Safranow Leszek Domanski |
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| Affiliation: | 1. Department of Pharmacology, Pomeranian Medical University in Szczecin, Powstancow Wlkp. 72, 70-111 Szczecin, Poland;2. Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Powstancow Wlkp. 72, 70-111 Szczecin, Poland;3. Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Powstancow Wlkp. 72, 70-111 Szczecin, Poland |
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| Abstract: | CD28 is a costimulatory molecule which plays an important role in T cell-mediated immune response and transplantation. The aim of the present study was to examine the association between the IVS3 + 17T/C (rs3116496:T/C) polymorphism in the CD28 gene and the development of delayed renal graft function (DGF), as well as the acute rejection and chronic allograft nephropathy. A total of 270 recipients of the first renal transplants were included in the study. SNP within the CD28 gene was genotyped using TaqMan genotyping assay.Acute rejection was diagnosed in 21.74% of the carriers of the TT genotype, 33.33% of CT carriers and 60.00% of CC homozygotes. The odds of acute rejection were statistically significantly higher in carriers of the C allele (with CT or CC genotype) compared with TT homozygotes (CC + CT vs TT: OR = 1.93, 95%CI = 1.10–3.39, p = 0.026). There were no statistically significant associations between CD28 gene polymorphism and DGF as well as chronic allograft nephropathy.The results of our study suggest an association between IVS3 + 17T/C polymorphism in the CD28 gene and acute kidney allograft rejection. |
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