Hyperlipidemia,tissue factor,coagulation, and simvastatin |
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| Authors: | Albert Phillip Owens James Robert Byrnes Nigel Mackman |
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| Institution: | 1. Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA;2. Montefiore Medical Center, Bronx, NY, USA;3. Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA;4. Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA;5. Center for Public Health Genomics, University of Virginia, VA, USA;6. Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA;7. Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA;8. Department of Radiology, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, USA;1. Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi’an 710069, China;2. Biomedicine Key Laboratory of Shaanxi Province, College of Life Science, Northwest University, Xi’an 710069, China;1. Department of Physiology & Biophysics, Mississippi Center for Obesity Research, University of Mississippi Medical Center, 2500 North State St, Jackson, MS 39216, USA;2. Department of Physiology and Pharmacology, University of Toledo College of Medicine, 3000 Arlington Avenue, Toledo, OH 43614, USA;1. Key Lab of Drug Metabolism and Pharmacokinetics, Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, PR China;2. Department of Pharmacology, Clinical Research Institute of Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210009, PR China;3. Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Pharmacy School at Yantai University, Yantai 264005, PR China;1. Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia;2. Division of Pharmaceutical Sciences, University of Missouri-Kansas City, Kansas City, MO, United States;3. Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Bratislava, Slovakia;4. Scientific Institute of Clinical and Experimental Lymphology-filial of the Institute of Cytology and Genetic Siberian Branch of Russian Academy of Science, Novosibirsk, Russia;5. Institute of Molecular Biology and Biophysics, Novosibirsk, Russia;6. The Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;1. Faculty of Medicine, Department of General Surgery, Gaziosmanpa?a University, Tokat, Turkey;2. Faculty of Medicine, Department of Physiology, Gaziosmanpa?a University, Tokat, Turkey;3. Faculty of Medicine, Department of Histology and Embryology, Gaziosmanpa?a University, Tokat, Turkey;4. Faculty of Medicine, Department of Biostatistic, Hitit University, Corum, Turkey;5. Faculty of Medicine, Department of Biochemistry, Gaziosmanpa?a University, Tokat, Turkey |
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| Abstract: | Hyperlipidemia affects millions of people worldwide and is a major risk factor for cardiovascular disease. People with hyperlipidemia have elevated levels of serum cholesterol and an increased risk of thrombosis. Studies have suggested that oxidized lipoproteins, such as oxidized low-density lipoprotein (oxLDL), contribute to the development of a pro-thrombotic state. In this review, we discuss our recent studies demonstrating a role for hematopoietic cell-derived tissue factor (TF) expression in the activation of coagulation and increased thrombosis associated with hyperlipidemia. In addition, we investigated the effect of simvastatin on TF expression and coagulation. We found that simvastatin reduced leukocyte TF expression, TF+ microparticles, and coagulation. These results and earlier studies suggest that the anti-coagulant activity of statins is due, in part, to their ability to reduce monocyte TF expression in patients with cardiovascular disease. |
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