拉克替醇散联合血必净注射液治疗自发性细菌性腹膜炎的效果及对血清PGE2、PGRN水平的影响

【目的】探讨拉克替醇散联合血必净注射液治疗自发性细菌性腹膜炎的临床疗效及对血清前列腺素E2(PGE2)、颗粒蛋白前体(PGRN)水平的影响。【方法】前瞻性选取2018年3月至2020年4月本院收治的88例自发性细菌性腹膜炎患者,根据随机数表法将其分为观察组和对照组,每组各44例。对照组在常规治疗的基础上给予拉克替醇散,观察组在对照组的基础上给予血必净注射液。比较两组治疗后临床效果、临床症状体征恢复正常的时间,并比较两组患者治疗后肝功能指标谷丙转氨酶(ALT)、总胆红素(TBIL)、白蛋白(Alb)、门冬氨酸氨基转移酶(AST)]及血清PGE2、PGRN水平。【结果】观察组临床有效率为88.64%(39/44),高于对照组的70.45%(31/44),差异有统计学意义(χ^2=4.470,P=0.035<0.05)。观察组体温恢复正常时间、腹痛消失时间、腹泻停止时间、腹部压痛消失时间、腹水培养阴性时间短于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者血清ALT、TBIL、AST、PGRN水平均低于治疗前,Alb、PGE2水平高于治疗前,差异有统计学意义(P<0.05);观察组血清ALT、TBIL、AST、PGRN水平低于对照组,Alb、PGE2水平高于对照组.差异有统计学意义(P<0.05)。观察组不良反应发生率为2.27%(1/44),低于对照组的6.82%(3/44),但差异无统计学意义(χ^2=0.262,P=0.609)。【结论】拉克替醇散联合血必净注射液治疗自发性细菌性腹膜炎,能加快患者临床症状体征恢复正常的时间,改善肝功能,疗效显著,安全性高,调控血清PGE2、PGRN水平可能是两种药物联合的一个作用机制。

Effect of Lactitol Powder and Xuehijing Injection on Bacterial Peritonitis and Its Influence on PGRN and PGE2

【Objective】To investigate the effect of Uctirol powder comhined with Xuehijing injection in the treatment of bacterial peritonitis and its influence on inflammatory mediators,total bilirubin(TBIL)and pros-taglandin E2(PGE2).【Methods】A total of 88 patients with bacterial peritonitis admitted to our hospital from March 2018 to April 2020 were selected and divided into two groups by random number tables with 44 cases in each group.On the basis of conventional treatment,the control group was given lactitol powder,and the oh servation group was given lactitol powder combined with Xuehijing injection.The efficacy and the recovery time of clinical symptoms and signs after 2 courses of treatment,liver function indexesserum alanine aminotransferase(ALT),total bilirubin(TBIL),albumin(Alb),aspartate aminotransferase(AST)],serum PGE2,pre-granulin(PGRN)before treatment,after treatment and adverse reactions were compared between the two groups.【Results】The total effective rate(88.64%)of the observation group after 2 courses of treatment was higher than that of the control group(70.45%)(P<0.05).The time of body tempeniture returning to normals the time of abdominal pain disappearing,the time of stopping diarrhea,the time of abdominal tenderness disappearing,and the negative time of ascites culture in the observation group were shorter than those in the control group(P<0.05).After 1 and 2 courses of treatment in the observation group,ALT,TBIL and AST were lower than the control groupf and Alb was higher than the control group(P<0.05).After 2 courses of treatment in the observation group.PGE2 was higher than the control group,and PGRN was lower than the control group(P<0.05).The incidence of adverse reactions in the observation group was 2.27%(1/44),compared with 6.82%(3/44)in the control group,there was no statistically significant differ-ence(P>0.05).【Conclusion】Lactitol powder combined widi Xucbijing injection in the treatment of bacterial peritonitis can speed up the recovery of clinical symptoms and signs,improve liver function.It has a significant effect and high safety.