妊娠期肝内胆汁淤积症的危险因素分析

目的 探讨妊娠期肝内胆汁淤积症(ICP)的危险因素,为改善孕妇及围产儿结局提供科学参考.方法 回顾性选取2018年1～6月重庆市南川区人民医院收治的90例ICP患者作为病例组,并随机选择同期分娩的90例非ICP孕产妇作为对照组.收集孕妇年龄、身高、体重、乙肝病毒感染、肝胆疾病、甲状腺疾病、血液系统疾病、妊娠期高血压以及...

Analysis of risk factors of intrahepatic cholestasis in pregnancy

Objective To explore the risk factors of intrahepatic cholestasis during pregnancy in pregnant,and to provide scientific reference for improving the outcome of pregnant women and perinatal infants.Methods Ninty ICP patients admitted to Chongqing Nanchuan District People's Hospital from January to June 2018 were selected retrospectively as the case group,and 90 non-ICP pregnant women who gave birth in our hospital during the same period were randomly selected as the control group.Pregnant women's age,height,weight,hepatitis B virus infection,liver and gallbladder disease,thyroid disease,blood system disease,gestational hypertension and gestational diabetes data were collected and analyzed using single-factor and multi-factor methods.Results Univariate analysis found that the average age of the case group[(27.50±4.30)years]were significantly higher than those of the control group[(26.30±3.60)years],and the differences were statistically significant(P<0.05).The proportion of elderly(≥35 years old)parturients in the case group was 16.67%,which was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The rates of ICP pregnant women with hepatobiliary disease,hepatitis B virus infection,hypertension,and diabetes were 17.78%,10.00%,28.89%,23.33%,which were significantly higher than those of the control group(5.56%,2.22%,15.56%,11.11%),and the difference was statistically significant(P<0.05).The results of multivariate analysis showed that older age,hepatobiliary disease,hypertension,and diabetes were pregnant women Risk factors for ICP(P<0.05).Conclusion Old age,combined hepatobiliary disease,combined high blood pressure,and combined diabetes are risk factors for ICP in pregnant women.The detection and treatment of these factors is of great significance to improve the outcome of pregnant women and perinatal infants.