| 宫颈组织免疫组化染色检测 P16/Ki67的表达在 LSIL和 ASC-US中的应用价值 |
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| 引用本文： | 杨海清,刘蕊婷,张月茹,李锡祥,党鸿蔚,任艳,崔晓宾,刘春霞,胡建明. 宫颈组织免疫组化染色检测 P16/Ki67的表达在 LSIL和 ASC-US中的应用价值[J]. 现代检验医学杂志, 2021, 0(1): 1-5. DOI: 10.3969/j.issn.1671-7414.2021.01.001 |
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| 作者姓名： | 杨海清 刘蕊婷 张月茹 李锡祥 党鸿蔚 任艳 崔晓宾 刘春霞 胡建明 |
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| 作者单位： | (1.石河子大学医学院,新疆石河子 832002;2. 石河子大学医学院第一附属医院,新疆石河子 832008） |
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| 基金项目： | 国家自然科学基金(NO:81760386);石河子大学大学生研究训练计划资助项目(SRP110)。 |
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| 摘 要： | 低级别鳞状上皮内病变（ low-grade squamous intraepithelial leasion,LSIL）和非典型鳞状细胞 (atypical squamous cells of undetermined signi?cance,ASC-US)是宫颈病变的常见类型,临床上主要采用 HPV-DNA检测对 LSIL和 ASC?US进行分流,但该分流方法存在漏诊率高等问题。目前,迫切需要一些生物标记物和检测方法来预测 LSIL和 ASC-US病例的转归,实现其分流管理。
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| 关 键 词： | 宫颈 P16 Ki67 低级别鳞状上皮内病变 非典型鳞状细胞 |
Application Value of Immunohistochemical Staining of Cervical Tissue to Detect the Expression of P16/Ki67 in LSIL and ASC-US |
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| YANG Hai-qing,LIU Rui-ting,ZHANG Yue-ru,LI Xi-xiang,DANG Hong-wei,REN Yan,CUI Xiao-bin,LIU Chun-xia,HU Jian-ming. Application Value of Immunohistochemical Staining of Cervical Tissue to Detect the Expression of P16/Ki67 in LSIL and ASC-US[J]. Journal of Modern Laboratory Medicine, 2021, 0(1): 1-5. DOI: 10.3969/j.issn.1671-7414.2021.01.001 |
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| Authors: | YANG Hai-qing LIU Rui-ting ZHANG Yue-ru LI Xi-xiang DANG Hong-wei REN Yan CUI Xiao-bin LIU Chun-xia HU Jian-ming |
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| Affiliation: | (1. Shihezi University School of Medicine,Xinjiang Shihezi 832002, China; 2. the First Affiliated Hospital of Medical College of Shihezi University, Xinjiang Shihezi 832008,China） |
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| Abstract: | Low grade squamous intraepithelial lesion(LSIL)and atypical squamous cells of undetermined significance(ASCUS)are common types of cervical lesion.Clinical determination of LSIL and ASC-US was mainly carried out by HPV-DNA detection,but this triage method has the problem of high rate of missed diagnosis.Nowadays,some biomarkers and detection methods were urgently needed to predict the outcome of LSIL and ASC-US,and achieve its distributive management. |
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| Keywords: | cervix uteri P16 Ki67 LSIL ASC-US |
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