The Brugada syndrome revisited |
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| Authors: | Meghavi Mashar Andrew J Kwok Richard Pinder Ian Sabir |
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| Institution: | 1. Downing College, Cambridge, UK;2. School of Public Health, Imperial College London, London, UK;3. Physiological Laboratory, Rayne Institute, University of Cambridge, St. Thomas'' Hospital, Westminster Bridge Road, London SE1 7EH, UK;1. Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan;2. Department of Advanced Therapeutics for Cardiovascular Diseases, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan;2. Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands;3. Krannert Institute of Cardiology, Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana;2. Mercy Heart & Vascular Institute, Sacramento, California;3. Helmsely Cardiac Arrhythmia Service, Mount Sinai School of Medicine, New York, New York |
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| Abstract: | The Brugada syndrome is a rare but well-defined cause of sudden cardiac death. The key underlying abnormality is a decrease in net depolarising current due to a genetic defect, though recent evidence also implicates structural abnormalities in some patients. Diagnosis requires a Brugada-type ECG as well as typical clinical features: such clinical considerations are currently key in guiding risk stratification and hence management. Whilst pharmacological therapies are under investigation, the only intervention with a robust evidence base remains insertion of an implantable cardioverter defibrillator. Further research will be required to allow more effective risk stratification and hence more rational therapy. |
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