粪便钙卫蛋白在肠易激综合征和炎症性肠病鉴别诊断中的意义分析

目的 探讨粪便钙卫蛋白(fecal calprotectin,FC)在肠易激综合征(irritable bowel syndrome,IBS)和炎症性肠病(inflammatory bowel disease,IBD)鉴别诊断中的意义.方法 选择2018年1月～7月江苏省中医院门诊及病房收治的IBS患者38例,IBD患...

Significance of Fecal Calprotectin in Differential Diagnosis of Irritable Bowel Syndrome and Inflammatory Bowel Disease

Objective To explore the application value of fecal calprotectin(FC)in differential diagnosis of irritable bowel syndrome(IBS)and inflammatory bowel disease(IBD).Methods From January 2018 to July 2018,38 patients with IBS and 114 patients with IBD in the outpatient and ward clinics of Jiangsu Provincial Hospital of Traditional Chinese Medicine were selected as the research objects.IBD group include 63 cases of ulcerative colitis(UC)and 51 cases of Crohn’s disease(CD).55 healthy people were selected as the healthy controls group.Enzyme-linked immunosorbent assay(ELISA)was used to determine the level of FC,and simultaneously to detect erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)in patients with IBD,and analyzed the differences in FC levels among the groups,as well as FC,ESR,CRP and disease activity index relevance.Results The level of FC in patients with IBD was significantly higher than that in IBS group and healthy control group,and the difference was statistically significant(q=15.897,18.523,all P<0.01),the level of FC in the UC group was higher than that in the CD group,and the difference was statistically significant(q=5.204,P<0.01).There was no significant difference in FC levels between the IBS group and the healthy group(q=0.318,P>0.05).Receiver operator characteristic curve(ROC)showed that the critical value of FC elevation was 159.5μg/g,and the best sensitivity and specificity for the diagnosis of IBD were 91.2%and 94.7%.FC,ESR and CRP in UC group were positively correlated with Mayo score(r=0.851,0.752 and 0.531,all P<0.01).FC,ESR and CRP in CD group were positively correlated with Crohn’s disease activity index(CDAI)score(r=0.796,0.693 and 0.476,all P<0.01).After treatment,patients with active inflammatory bowel disease showed a significant decrease in FC levels(t=17.543,11.313,all P<0.01).Conclusion FC can be used as a good indicator to distinguish IBS and IBD and to judge the activity and efficacy of IBD.