Defining the level of evidence for technology adoption in the localized prostate cancer pathway |
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| Authors: | Massimo Valerio Ahmed El-Shater Bosaily Mark Emberton Hashim U Ahmed |
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| Institution: | 1. Division of Surgery and Interventional Science, University College London, London, UK;2. Department of Urology, University College London Hospitals NHS Foundation Trust, London, UK;3. Department of Urology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland |
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| Abstract: | New technologies in prostate cancer are attempting to change the current prostate cancer pathway by aiming to reduce harms while maintaining the benefits associated with screening, diagnosis, and treatment. In this article, we discuss the optimal evaluation that new technologies should undergo to provide level 1 evidence typically required to change the practice. With this in mind, we focus on feasible and pragmatic trials that could be delivered in a timely fashion by many centers while retaining primary outcomes that focus on clinically meaningful outcomes. |
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| Keywords: | Focal therapy Health technology assessment MRI Prostate cancer Targeted biopsy Trials |
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