An emerging role for the miR-26 family in cardiovascular disease |
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Authors: | Basak Icli Pranav Dorbala Mark W. Feinberg |
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Affiliation: | 1. School of Biological Sciences, University of Wollongong, Wollongong, NSW 2522, Australia;2. Illawarra Health and Medical Research Institute, Wollongong, NSW 2522, Australia;3. Albion Park Veterinary Hospital, Albion Park, NSW 2527, Australia |
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Abstract: | In response to acute myocardial infarction (MI), a complex series of cellular and molecular signaling events orchestrate the myocardial remodeling that ensues weeks to months after injury. Clinical, epidemiological, and pathological studies demonstrate that inadequate or impaired angiogenesis after myocardial injury is often associated with decreased left ventricular (LV) function and clinical outcomes. The microRNA family, miR-26, plays diverse roles in regulating key aspects of cellular growth, development, and activation. Recent evidence supports a central role for the miR-26 family in cardiovascular disease by controlling critical signaling pathways, such as BMP/SMAD1 signaling, and targets relevant to endothelial cell growth, angiogenesis, and LV function post-MI. Emerging studies of the miR-26 family in other cell types including vascular smooth muscle cells, cardiac fibroblasts, and cardiomyocytes suggest that miR-26 may bear important implications for a range of cardiovascular repair mechanisms. This review examines the current knowledge of the miR-26 family’s role in key cell types that critically control cardiovascular disease under pathological and physiological stimuli. |
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