系统性红斑狼疮患者血清IgG水平正常及升高与相关免疫学实验室指标的相关分析

目的 探讨系统性红斑狼疮患者(systemic lupus erythematosus,SLE)中免疫球蛋白G(immunoglobulin G,IgG)正常与IgG升高的患者,其抗核抗体(antinuclear antibody,ANA)滴度、抗双链DNA(double-strand DNA,ds-DNA)抗体及抗可...

Correlation Analysis between Normal and Elevated Serum IgG Levels and Related Immunological Laboratory Indexes in Patients with Systemic Lupus Erythematosus

Objective To compare the characteristics of ANA titer,anti dsDNA and ENA in patients of systemic lupus erythematosus(SLE)with normal level of IgG to those with increased level of IgG.Methods A total of 150 newly diagnosed SLE patients,including 62 patients with lupus nephritis were selected in the study.All patients were obtained from the First Affiliated Hospital of Air Force Military Medical University from June 2019 to December 2019.The rate scatter turbidimetric method was used to detect immunoglobulins IgA,IgG,IgM and complement C3,C4 levels in the serum of SLE patients.Indirect immunofluorescence(IIF)and linear immunoblotting(LIA)were used to detect anti-nuclear antibodies ANA,anti-ds-DNA antibodies and ENA.Comparing the differences in laboratory indicators between patients with normal IgG and increased IgG groups.Results The serum IgA(z=-3.64,P<0.05)and IgM levels of SLE patients in IgG normal group was lower than that in IgG increased group.The level of C3 and C4 was higher in IgG normal group with no statistical significance.The positive percentage of ds-DNA,SSA,Ro-52 and AnuA in IgG normal group was lower than that in IgG increased group(χ^2=4.985,7.479,8.974 and 5.637,all P<0.05),but there was no difference for nRNP/Sm,Sm,SSB,AHA and ARPA between the two groups(χ^2=0.005~2.050,all P>0.05).The incidence rate of lupus nephritis was not different between the two groups.Conclusion The SLE patients with normal IgG could be seen frequently in clinic,the positive rate of autoantibodies was lower,and the incidence rate of lupus nephritis was not different from that of IgG increased group.Therefore,the patients with normal IgG SLE should be paid attention by clinicians to reduce their missed diagnosis and misdiagnosis.